FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115428779> ?p ?o ?g. }

• W2115428779 abstract "Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogenesis through binding to the receptor Ob-R present on ECs by stimulating and initiating new capillary like structures from ECs. Various in vivo studies indicate that leptin has diverse effect on angiogenesis. A few reports have showed that leptin exerts pro angiogenic effects while some suggested that it has antiangiogenic potential. It is theoretically highly important to understand the effect of leptin on angiogenesis to use as a therapeutic molecule in various angiogenesis related pathological conditions. Chicken chorio allantoic membrane (CAM) on 9th day of incubation was incubated with 1, 3 and 5 μg concentration of HRL for 72 h using gelatin sponge. Images where taken after every 24 h of incubation and analysed with Angioguant software. The treated area was observed under microscope and histological evaluation was performed for the same. Tissue thickness was calculated morphometrically from haematoxylin and eosin stained cross sections. Reverse transcriptase PCR and immunohistochemistry were also performed to study the gene and protein level expression of angiogenic molecules.HRL has the ability to induce new vessel formation at the treated area and growth of the newly formed vessels and cellular morphological changes occur in a dose dependent manner. Increase in the tissue thickness at the treated area is suggestive of initiation of new capillary like structures. Elevated mRNA and protein level expression of VEGF165 and MMP2 along with the activation of ECs as demonstrated by the presence of CD34 expression supports the neovascularization potential of HRL.Angiogenic potential of HRL depends on the concentration and time of incubation and is involved in the activation of ECs along with the major interaction of VEGF 165 and MMP2. It is also observed that 3 μg of HRL exhibits maximum angiogenic potential at 72 h of incubation. Thus our data suggest that dose dependent angiogenic potential HRL could provide a novel role in angiogenic dependent therapeutics such as ischemia and wound healing conditions." @default.
• W2115428779 created "2016-06-24" @default.
• W2115428779 creator A5005449282 @default.
• W2115428779 creator A5010598838 @default.
• W2115428779 date "2015-06-10" @default.
• W2115428779 modified "2023-09-26" @default.
• W2115428779 title "In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane" @default.
• W2115428779 cites W1555986393 @default.
• W2115428779 cites W1964417650 @default.
• W2115428779 cites W1990692512 @default.
• W2115428779 cites W1996639615 @default.
• W2115428779 cites W1996713062 @default.
• W2115428779 cites W2000845874 @default.
• W2115428779 cites W2012886027 @default.
• W2115428779 cites W2020060564 @default.
• W2115428779 cites W2027339934 @default.
• W2115428779 cites W2039071181 @default.
• W2115428779 cites W2041708400 @default.
• W2115428779 cites W2042057695 @default.
• W2115428779 cites W2044240271 @default.
• W2115428779 cites W2045618923 @default.
• W2115428779 cites W2066960729 @default.
• W2115428779 cites W2067183464 @default.
• W2115428779 cites W2070196393 @default.
• W2115428779 cites W2083908078 @default.
• W2115428779 cites W2091078679 @default.
• W2115428779 cites W2109197670 @default.
• W2115428779 cites W2111796479 @default.
• W2115428779 cites W2115452170 @default.
• W2115428779 cites W2117182506 @default.
• W2115428779 cites W2121311096 @default.
• W2115428779 cites W2124423413 @default.
• W2115428779 cites W2125596540 @default.
• W2115428779 cites W2126426760 @default.
• W2115428779 cites W2132660240 @default.
• W2115428779 cites W2134582008 @default.
• W2115428779 cites W2135405968 @default.
• W2115428779 cites W2140456158 @default.
• W2115428779 cites W2148309788 @default.
• W2115428779 cites W2152492593 @default.
• W2115428779 cites W2157816281 @default.
• W2115428779 cites W2161424574 @default.
• W2115428779 cites W2162147695 @default.
• W2115428779 doi "https://doi.org/10.1186/s40659-015-0021-z" @default.
• W2115428779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4470073" @default.
• W2115428779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26060038" @default.
• W2115428779 hasPublicationYear "2015" @default.
• W2115428779 type Work @default.
• W2115428779 sameAs 2115428779 @default.
• W2115428779 citedByCount "15" @default.
• W2115428779 countsByYear W21154287792015 @default.
• W2115428779 countsByYear W21154287792016 @default.
• W2115428779 countsByYear W21154287792017 @default.
• W2115428779 countsByYear W21154287792018 @default.
• W2115428779 countsByYear W21154287792019 @default.
• W2115428779 countsByYear W21154287792020 @default.
• W2115428779 countsByYear W21154287792021 @default.
• W2115428779 countsByYear W21154287792022 @default.
• W2115428779 countsByYear W21154287792023 @default.
• W2115428779 crossrefType "journal-article" @default.
• W2115428779 hasAuthorship W2115428779A5005449282 @default.
• W2115428779 hasAuthorship W2115428779A5010598838 @default.
• W2115428779 hasBestOaLocation W21154287791 @default.
• W2115428779 hasConcept C121608353 @default.
• W2115428779 hasConcept C126322002 @default.
• W2115428779 hasConcept C134018914 @default.
• W2115428779 hasConcept C150903083 @default.
• W2115428779 hasConcept C170493617 @default.
• W2115428779 hasConcept C171089720 @default.
• W2115428779 hasConcept C185592680 @default.
• W2115428779 hasConcept C196843134 @default.
• W2115428779 hasConcept C203014093 @default.
• W2115428779 hasConcept C204232928 @default.
• W2115428779 hasConcept C207001950 @default.
• W2115428779 hasConcept C2776636583 @default.
• W2115428779 hasConcept C2778765379 @default.
• W2115428779 hasConcept C2779013556 @default.
• W2115428779 hasConcept C2780394083 @default.
• W2115428779 hasConcept C2780613262 @default.
• W2115428779 hasConcept C502942594 @default.
• W2115428779 hasConcept C511355011 @default.
• W2115428779 hasConcept C55493867 @default.
• W2115428779 hasConcept C71924100 @default.
• W2115428779 hasConcept C86803240 @default.
• W2115428779 hasConcept C95444343 @default.
• W2115428779 hasConcept C97230052 @default.
• W2115428779 hasConceptScore W2115428779C121608353 @default.
• W2115428779 hasConceptScore W2115428779C126322002 @default.
• W2115428779 hasConceptScore W2115428779C134018914 @default.
• W2115428779 hasConceptScore W2115428779C150903083 @default.
• W2115428779 hasConceptScore W2115428779C170493617 @default.
• W2115428779 hasConceptScore W2115428779C171089720 @default.
• W2115428779 hasConceptScore W2115428779C185592680 @default.
• W2115428779 hasConceptScore W2115428779C196843134 @default.
• W2115428779 hasConceptScore W2115428779C203014093 @default.
• W2115428779 hasConceptScore W2115428779C204232928 @default.
• W2115428779 hasConceptScore W2115428779C207001950 @default.
• W2115428779 hasConceptScore W2115428779C2776636583 @default.
• W2115428779 hasConceptScore W2115428779C2778765379 @default.
• W2115428779 hasConceptScore W2115428779C2779013556 @default.

• next