Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115429230> ?p ?o ?g. }
- W2115429230 endingPage "1125" @default.
- W2115429230 startingPage "1110" @default.
- W2115429230 abstract "The septins are GTP-binding, filament-forming proteins that are involved in cytokinesis and other processes. In the yeast Saccharomyces cerevisiae, the septins are recruited to the presumptive bud site at the cell cortex, where they form a ring through which the bud emerges. We report here that in wild-type cells, the septins typically become detectable in the vicinity of the bud site several minutes before ring formation, but the ring itself is the first distinct structure that forms. Septin recruitment depends on activated Cdc42p but not on the normal pathway for bud-site selection. Recruitment occurs in the absence of F-actin, but ring formation is delayed. Mutant phenotypes and suppression data suggest that the Cdc42p effectors Gic1p and Gic2p, previously implicated in polarization of the actin cytoskeleton, also function in septin recruitment. Two-hybrid, in vitro protein binding, and coimmunoprecipitation data indicate that this role involves a direct interaction of the Gic proteins with the septin Cdc12p." @default.
- W2115429230 created "2016-06-24" @default.
- W2115429230 creator A5005687361 @default.
- W2115429230 creator A5032880124 @default.
- W2115429230 creator A5034977910 @default.
- W2115429230 creator A5049142202 @default.
- W2115429230 creator A5054556504 @default.
- W2115429230 creator A5065478524 @default.
- W2115429230 creator A5067450178 @default.
- W2115429230 creator A5075986364 @default.
- W2115429230 creator A5082281557 @default.
- W2115429230 creator A5085625110 @default.
- W2115429230 date "2006-03-01" @default.
- W2115429230 modified "2023-10-16" @default.
- W2115429230 title "Role of a Cdc42p Effector Pathway in Recruitment of the Yeast Septins to the Presumptive Bud Site" @default.
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