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• W2115436779 abstract "The present study aimed to prepare and evaluate polymeric micelles conjugated with folic acid through <TEX>${alpha}$</TEX>- or <TEX>${gamma}$</TEX>-carboxyl groups for antitumor efficacy. The isomeric block copolymers, <TEX>${alpha}$</TEX>- and <TEX>${gamma}$</TEX>-folate-polyethyleneglycol-distearoyl phosphatidylethanolamine (<TEX>${alpha}$</TEX>- and <TEX>${gamma}$</TEX>-Fol-PEG-DSPE), were produced by solid phase peptide synthesis. Three types of doxorubicin (DOX)-loaded polymeric micelles (MPEG-DSPE-DOX and <TEX>${alpha}$</TEX>- / <TEX>${gamma}$</TEX>-Fol-PEG-DSPEDOX micelles) were prepared via the film formation method. Compared with MPEG-DSPE-DOX micelles, the <TEX>${alpha}$</TEX>- / <TEX>${gamma}$</TEX>-Fol-PEG-DSPE-DOX micelles presented a higher cellular uptake behavior in the live cell study. Cell viability percentages were 81.8%, 57.3%, 56.6% at 2 hours for MPEG-DSPE-DOX, <TEX>${alpha}$</TEX>- and <TEX>${gamma}$</TEX>-Fol-PEG-DSPE-DOX micelles, respectively (p<0.05). Using the KB xenograft tumor model, both <TEX>${alpha}$</TEX>- and <TEX>${gamma}$</TEX>-folate-conjugated micelles were found to have better antitumor effects with lower toxicity in comparison with MPEG-DSPE-DOX micelles. No difference in in vivo antitumor efficacy was found between <TEX>${alpha}$</TEX>- and <TEX>${gamma}$</TEX>-Fol-PEG-DSPE-DOX micelles. The folate-conjugated micelles might be a potentially useful strategy for tumor targeting of therapeutic agents, whether grafting with folic acid through <TEX>${alpha}$</TEX>- or <TEX>${gamma}$</TEX>-carboxyl groups." @default.
• W2115436779 created "2016-06-24" @default.
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• W2115436779 date "2014-09-15" @default.
• W2115436779 modified "2023-10-12" @default.
• W2115436779 title "Isomeric Folate-Conjugated Polymeric Micelles Bind to Folate Receptors and Display Anticancer Effects" @default.
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• W2115436779 doi "https://doi.org/10.7314/apjcp.2014.15.17.7363" @default.
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