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• W2115445465 abstract "Adequate plasma volume (PV) and extracellular fluid (ECF) volume are essential for blood pressure and fluid regulation. We tested the hypotheses that combined progesterone (P 4 )-estrogen (E 2 ) administration would increase ECF volume with proportional increases in PV, but that P 4 would have little independent effect on either PV or ECF volume. We further hypothesized that this P 4 -E 2 -induced fluid expansion would be a function of renin-angiotensin-aldosterone system stimulation. We suppressed P 4 and E 2 with a gonadotropin-releasing hormone (GnRH) antagonist in eight women (25 ± 2 yr) for 16 days; P 4 (200 mg/day) was added for days 5–16 (P 4 ) and 17β-estradiol (2 × 0.1 mg/day patches) for days 13–16 (P 4 -E 2 ). On days 2 (GnRH antagonist), 9 (P 4 ), and 16 (P 4 -E 2 ), we estimated ECF and PV. To determine the rate of protein and thus water movement across the ECF, we also measured transcapillary escape rate of albumin. In P 4 , [Formula: see text] increased from 2.5 ± 1.3 to 12.0 ± 2.8 ng/ml ( P < 0.05) with no change in [Formula: see text] (21.5 ± 9.4 to 8.6 ± 2.0 pg/ml). In P 4 -E 2 , plasma concentration of P 4 remained elevated (11.3 ± 2.7 ng/ml) and plasma concentration of E 2 increased to 254.1 ± 52.7 pg/ml ( P < 0.05). PV increased during P 4 (46.6 ± 2.5 ml/kg) and P 4 -E 2 (48.4 ± 3.9 ml/kg) compared with GnRH antagonist (43.3 ± 3.2 ml/kg; P < 0.05), as did ECF (206 ± 19, 244 ± 25, and 239 ± 27 ml/kg for GnRH antagonist, P 4 , and P 4 -E 2 , respectively; P < 0.05). Transcapillary escape rate of albumin was lowest during P 4 -E 2 (5.8 ± 1.3, 3.5 ± 1.7, and 2.2 ± 0.4%/h for GnRH antagonist, P 4 , and P 4 -E 2 , respectively; P < 0.05). Serum aldosterone increased during P 4 and P 4 -E 2 compared with GnRH antagonist (79 ± 17, 127 ± 13, and 171 ± 25 pg/ml for GnRH antagonist, P 4 , and P 4 -E 2 , respectively; P < 0.05), but plasma renin activity and plasma concentration of ANG II were only increased by P 4 -E 2 . This study is the first to isolate P 4 effects on ECF; however, the mechanisms for the ECF and PV expansion have not been clearly defined." @default.
• W2115445465 created "2016-06-24" @default.
• W2115445465 creator A5025562404 @default.
• W2115445465 creator A5073212927 @default.
• W2115445465 date "2005-06-01" @default.
• W2115445465 modified "2023-09-26" @default.
• W2115445465 title "Progesterone increases plasma volume independent of estradiol" @default.
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• W2115445465 doi "https://doi.org/10.1152/japplphysiol.00031.2005" @default.
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