Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115447029> ?p ?o ?g. }
- W2115447029 abstract "Recent imaging connectomics studies have demonstrated that the spontaneous human brain functional networks derived from resting-state functional MRI (R-fMRI) include many non-trivial topological properties, such as highly efficient small-world architecture and densely connected hub regions. However, very little is known about dynamic functional connectivity (D-FC) patterns of spontaneous human brain networks during rest and about how these spontaneous brain dynamics are constrained by the underlying structural connectivity. Here, we combined sub-second multiband R-fMRI data with graph-theoretical approaches to comprehensively investigate the dynamic characteristics of the topological organization of human whole-brain functional networks, and then employed diffusion imaging data in the same participants to further explore the associated structural substrates. At the connection level, we found that human whole-brain D-FC patterns spontaneously fluctuated over time, while homotopic D-FC exhibited high connectivity strength and low temporal variability. At the network level, dynamic functional networks exhibited time-varying but evident small-world and assortativity architecture, with several regions (e.g., insula, sensorimotor cortex and medial prefrontal cortex) emerging as functionally persistent hubs (i.e., highly connected regions) while possessing large temporal variability in their degree centrality. Finally, the temporal characteristics (i.e., strength and variability) of the connectional and nodal properties of the dynamic brain networks were significantly associated with their structural counterparts. Collectively, we demonstrate the economical, efficient, and flexible characteristics of dynamic functional coordination in large-scale human brain networks during rest, and highlight their relationship with underlying structural connectivity, which deepens our understandings of spontaneous brain network dynamics in humans." @default.
- W2115447029 created "2016-06-24" @default.
- W2115447029 creator A5005075027 @default.
- W2115447029 creator A5009092975 @default.
- W2115447029 creator A5011305571 @default.
- W2115447029 creator A5011734445 @default.
- W2115447029 creator A5013029599 @default.
- W2115447029 creator A5039562624 @default.
- W2115447029 creator A5058016509 @default.
- W2115447029 creator A5072439406 @default.
- W2115447029 creator A5086148125 @default.
- W2115447029 date "2015-09-04" @default.
- W2115447029 modified "2023-10-14" @default.
- W2115447029 title "Spontaneous functional network dynamics and associated structural substrates in the human brain" @default.
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