Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115457093> ?p ?o ?g. }
- W2115457093 endingPage "509" @default.
- W2115457093 startingPage "499" @default.
- W2115457093 abstract "We aimed to compare clinical outcomes and safety after sorafenib therapy between patients with Barcelona Clinic Liver Cancer (BCLC) stage B or C hepatocellular carcinoma (HCC) aged ≥75 years (aged group, n=179) and those with BCLC stage B or C HCC aged <75 years (control group, n=279).We compared overall survival (OS), progression free survival (PFS), best treatment response and sorafenib related serious adverse events (SAEs) of grade 3 or more in the two groups. Furthermore, for reducing the selection bias, we compared clinical outcome of these two groups using propensity score matching analysis.The median OS and PFS intervals were 9.7 and 3.8 months in the aged group and 8.2 and 3.3 months in the control group (P=0.641 for OS and P=0.068 for PFS). Disease control rates were 49.2% (88/179) in the aged group and 49.1% (137/279) in the control group (P>0.999). Objective response rates were 15.1% (27/179) in the aged group and 14.3% (40/279) in the control group (P=0.892). Treatment related SAEs of grade 3 or more were observed in 51 patients (28.5%) in the aged group and in 69 patients (24.7%) in the control group (P=0.385). In the propensity score matched cohort (132 pairs), no significant difference in the two groups was observed in terms of OS (P=0.898) and PFS (P=0.407).In BCLC stage B or C HCC patients treated with sorafenib, life expectancy, disease progression, treatment efficacy and SAEs are unaffected by age over 75 years." @default.
- W2115457093 created "2016-06-24" @default.
- W2115457093 creator A5003312518 @default.
- W2115457093 creator A5018535039 @default.
- W2115457093 creator A5021816409 @default.
- W2115457093 creator A5057557751 @default.
- W2115457093 creator A5062645991 @default.
- W2115457093 creator A5063339600 @default.
- W2115457093 creator A5066924600 @default.
- W2115457093 creator A5067005093 @default.
- W2115457093 creator A5079893085 @default.
- W2115457093 creator A5080874384 @default.
- W2115457093 date "2014-01-01" @default.
- W2115457093 modified "2023-10-05" @default.
- W2115457093 title "Sorafenib Therapy for BCLC Stage B/C Hepatocellular Carcinoma; Clinical Outcome and Safety in Aged Patients: A Multicenter Study in Japan" @default.
- W2115457093 cites W1511799995 @default.
- W2115457093 cites W1582955307 @default.
- W2115457093 cites W1589304837 @default.
- W2115457093 cites W1740935122 @default.
- W2115457093 cites W1965756936 @default.
- W2115457093 cites W1971837077 @default.
- W2115457093 cites W1978840623 @default.
- W2115457093 cites W1979246588 @default.
- W2115457093 cites W1985719098 @default.
- W2115457093 cites W1986490872 @default.
- W2115457093 cites W1994193851 @default.
- W2115457093 cites W2000307707 @default.
- W2115457093 cites W2016201187 @default.
- W2115457093 cites W2016278725 @default.
- W2115457093 cites W2018753012 @default.
- W2115457093 cites W2020857855 @default.
- W2115457093 cites W2024134346 @default.
- W2115457093 cites W2024450952 @default.
- W2115457093 cites W2038767064 @default.
- W2115457093 cites W2042209473 @default.
- W2115457093 cites W2047601457 @default.
- W2115457093 cites W2049902956 @default.
- W2115457093 cites W2060151208 @default.
- W2115457093 cites W2071030148 @default.
- W2115457093 cites W2074788213 @default.
- W2115457093 cites W2075427039 @default.
- W2115457093 cites W2075693302 @default.
- W2115457093 cites W2078893799 @default.
- W2115457093 cites W2079254150 @default.
- W2115457093 cites W2079586464 @default.
- W2115457093 cites W2087055449 @default.
- W2115457093 cites W2094691956 @default.
- W2115457093 cites W2104397763 @default.
- W2115457093 cites W2113023735 @default.
- W2115457093 cites W2116858453 @default.
- W2115457093 cites W2121690051 @default.
- W2115457093 cites W2123417186 @default.
- W2115457093 cites W2128153851 @default.
- W2115457093 cites W2156871508 @default.
- W2115457093 cites W2161558746 @default.
- W2115457093 cites W2162392094 @default.
- W2115457093 cites W2167231879 @default.
- W2115457093 cites W2260218741 @default.
- W2115457093 cites W2288626366 @default.
- W2115457093 cites W22893132 @default.
- W2115457093 cites W2321020163 @default.
- W2115457093 cites W2412304370 @default.
- W2115457093 cites W2417228207 @default.
- W2115457093 cites W25524845 @default.
- W2115457093 cites W3142844290 @default.
- W2115457093 doi "https://doi.org/10.7150/jca.9257" @default.
- W2115457093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067509" @default.
- W2115457093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24963354" @default.
- W2115457093 hasPublicationYear "2014" @default.
- W2115457093 type Work @default.
- W2115457093 sameAs 2115457093 @default.
- W2115457093 citedByCount "26" @default.
- W2115457093 countsByYear W21154570932014 @default.
- W2115457093 countsByYear W21154570932015 @default.
- W2115457093 countsByYear W21154570932016 @default.
- W2115457093 countsByYear W21154570932017 @default.
- W2115457093 countsByYear W21154570932020 @default.
- W2115457093 countsByYear W21154570932021 @default.
- W2115457093 countsByYear W21154570932022 @default.
- W2115457093 crossrefType "journal-article" @default.
- W2115457093 hasAuthorship W2115457093A5003312518 @default.
- W2115457093 hasAuthorship W2115457093A5018535039 @default.
- W2115457093 hasAuthorship W2115457093A5021816409 @default.
- W2115457093 hasAuthorship W2115457093A5057557751 @default.
- W2115457093 hasAuthorship W2115457093A5062645991 @default.
- W2115457093 hasAuthorship W2115457093A5063339600 @default.
- W2115457093 hasAuthorship W2115457093A5066924600 @default.
- W2115457093 hasAuthorship W2115457093A5067005093 @default.
- W2115457093 hasAuthorship W2115457093A5079893085 @default.
- W2115457093 hasAuthorship W2115457093A5080874384 @default.
- W2115457093 hasBestOaLocation W21154570931 @default.
- W2115457093 hasConcept C126322002 @default.
- W2115457093 hasConcept C143998085 @default.
- W2115457093 hasConcept C146357865 @default.
- W2115457093 hasConcept C151730666 @default.
- W2115457093 hasConcept C17923572 @default.
- W2115457093 hasConcept C197934379 @default.
- W2115457093 hasConcept C2776231280 @default.