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- W2115471036 abstract "In this study, we propose a novel methodology to produce nanosized polymeric nanoparticles based on the polymethacrylate polymer Eudragit L100. The role of wet-nanogrinding on the grinding of eudragit L100 powder has been investigated by varying important grinding parameters such as media bead size, concentration and type of stabilizers, polymer concentration, agitation speed, and milling time. In order to obtain a dried powder that allows further formulation of these particles, freeze-drying and spray-drying methodologies were compared. The physical profile of optimized powder nanoparticles were then tested in electrolyte solutions, which mimic the conditions found in the human gastrointestinal tract. It was shown that the combination of two different types of stabilizers both electrostatic (SLS) and steric (PVA) led to a smaller particle size and a better redispersion in both electrolyte and acidic media that mimic the conditions in vivo. Further studies will be carried out in order to produce bioactive loaded nanoparticles by this procedure possibly with improved solubility and /or bioavailability in vivo." @default.
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- W2115471036 date "2010-01-01" @default.
- W2115471036 modified "2023-09-26" @default.
- W2115471036 title "Desenvolvimento e caracterização de nanopartículas de eudragit L100 preparadas pela técnica de nanomoagem húmida para posterior incorporação de compostos bioactivos" @default.
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