Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115478977> ?p ?o ?g. }
- W2115478977 endingPage "1347" @default.
- W2115478977 startingPage "1327" @default.
- W2115478977 abstract "Human ageing is characterized by a progressive loss of physiological functions, increased tissue damage and defects in various tissue renewal systems. Age-related decreases of the cellular replicative capacity can be reproduced by in vitro assays of cellular ageing. When diploid human fibroblasts reach their finite lifespan, they enter an irreversible G1 growth arrest status referred to as replicative senescence. While deregulation of programmed cell death (apoptosis) is a key feature of age-related pathology in several tissues, this is not reflected in the standard in vitro senescence model of human fibroblasts, and the role of apoptosis during cellular ageing remains unclear. We have analyzed replicative senescence of human umbilical vein endothelial cells (HUVEC) in vitro and found that senescent HUVEC also arrest in the G1 phase of the cell cycle but, unlike fibroblasts, accumulate with a 4N DNA content, indicative of polyploidization. In contrast to human fibroblasts, senescent endothelial cells display a considerable increase in spontaneous apoptosis. The data imply that age-dependent apoptosis is a regular feature of human endothelial cells and suggest cell type specific differences in human ageing." @default.
- W2115478977 created "2016-06-24" @default.
- W2115478977 creator A5006946665 @default.
- W2115478977 creator A5007353087 @default.
- W2115478977 creator A5036916784 @default.
- W2115478977 creator A5073234943 @default.
- W2115478977 creator A5076215352 @default.
- W2115478977 creator A5083280772 @default.
- W2115478977 date "2001-08-01" @default.
- W2115478977 modified "2023-10-18" @default.
- W2115478977 title "Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis" @default.
- W2115478977 cites W1544564404 @default.
- W2115478977 cites W1576276646 @default.
- W2115478977 cites W1966318223 @default.
- W2115478977 cites W1973573758 @default.
- W2115478977 cites W1979129905 @default.
- W2115478977 cites W1988840246 @default.
- W2115478977 cites W1994681448 @default.
- W2115478977 cites W1998108152 @default.
- W2115478977 cites W1999330214 @default.
- W2115478977 cites W2000866311 @default.
- W2115478977 cites W2004878760 @default.
- W2115478977 cites W2013576756 @default.
- W2115478977 cites W2015871681 @default.
- W2115478977 cites W2018537155 @default.
- W2115478977 cites W2025213003 @default.
- W2115478977 cites W2032428064 @default.
- W2115478977 cites W2033149433 @default.
- W2115478977 cites W2048721919 @default.
- W2115478977 cites W2049680942 @default.
- W2115478977 cites W2049783958 @default.
- W2115478977 cites W2050551830 @default.
- W2115478977 cites W2052361881 @default.
- W2115478977 cites W2065363374 @default.
- W2115478977 cites W2068682897 @default.
- W2115478977 cites W2073360627 @default.
- W2115478977 cites W2082979162 @default.
- W2115478977 cites W2084533871 @default.
- W2115478977 cites W2099682050 @default.
- W2115478977 cites W2104908670 @default.
- W2115478977 cites W2106319388 @default.
- W2115478977 cites W2114738441 @default.
- W2115478977 cites W2122500818 @default.
- W2115478977 cites W2133160109 @default.
- W2115478977 cites W2136306650 @default.
- W2115478977 cites W2141232186 @default.
- W2115478977 cites W2145509843 @default.
- W2115478977 cites W2147424761 @default.
- W2115478977 cites W2157033538 @default.
- W2115478977 cites W2157603347 @default.
- W2115478977 cites W2159329277 @default.
- W2115478977 cites W2164719183 @default.
- W2115478977 cites W2165209574 @default.
- W2115478977 cites W2166151945 @default.
- W2115478977 cites W2186089638 @default.
- W2115478977 cites W2422506963 @default.
- W2115478977 cites W4240650983 @default.
- W2115478977 cites W4255665700 @default.
- W2115478977 doi "https://doi.org/10.1016/s0531-5565(01)00105-x" @default.
- W2115478977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11602208" @default.
- W2115478977 hasPublicationYear "2001" @default.
- W2115478977 type Work @default.
- W2115478977 sameAs 2115478977 @default.
- W2115478977 citedByCount "187" @default.
- W2115478977 countsByYear W21154789772012 @default.
- W2115478977 countsByYear W21154789772013 @default.
- W2115478977 countsByYear W21154789772014 @default.
- W2115478977 countsByYear W21154789772015 @default.
- W2115478977 countsByYear W21154789772016 @default.
- W2115478977 countsByYear W21154789772017 @default.
- W2115478977 countsByYear W21154789772018 @default.
- W2115478977 countsByYear W21154789772019 @default.
- W2115478977 countsByYear W21154789772020 @default.
- W2115478977 countsByYear W21154789772021 @default.
- W2115478977 countsByYear W21154789772022 @default.
- W2115478977 countsByYear W21154789772023 @default.
- W2115478977 crossrefType "journal-article" @default.
- W2115478977 hasAuthorship W2115478977A5006946665 @default.
- W2115478977 hasAuthorship W2115478977A5007353087 @default.
- W2115478977 hasAuthorship W2115478977A5036916784 @default.
- W2115478977 hasAuthorship W2115478977A5073234943 @default.
- W2115478977 hasAuthorship W2115478977A5076215352 @default.
- W2115478977 hasAuthorship W2115478977A5083280772 @default.
- W2115478977 hasConcept C104317684 @default.
- W2115478977 hasConcept C105696609 @default.
- W2115478977 hasConcept C143191323 @default.
- W2115478977 hasConcept C1491633281 @default.
- W2115478977 hasConcept C190283241 @default.
- W2115478977 hasConcept C190474072 @default.
- W2115478977 hasConcept C202751555 @default.
- W2115478977 hasConcept C29537977 @default.
- W2115478977 hasConcept C31573885 @default.
- W2115478977 hasConcept C500499127 @default.
- W2115478977 hasConcept C522857546 @default.
- W2115478977 hasConcept C54355233 @default.
- W2115478977 hasConcept C86803240 @default.
- W2115478977 hasConcept C95444343 @default.
- W2115478977 hasConceptScore W2115478977C104317684 @default.