FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115484963> ?p ?o ?g. }

• W2115484963 endingPage "598" @default.
• W2115484963 startingPage "590" @default.
• W2115484963 abstract "The PC12 rat pheochromocytoma cell line is widely used to study neuronal differentiation by growth factors. In response to nerve growth factor (NGF) and basic fibroblast growth factor (bFGF), PC12 cells differentiate into sympathetic-like neurons and become electrically excitable. Using whole cell patch-clamp recording, with barium as a charge carrier, we looked at the effects of bFGF on calcium channel expression as reflected by changes in barium current amplitudes normalized to cell membrane area. Similar to the effect reported for NGF, we show that 7 day treatment with bFGF increased the barium current approximately 4-fold. The largest contributor to the increase in barium current with bFGF treatment is a 6-fold increase in the high threshold voltage activated Ω-conotoxin sensitive barium current. Smaller increases in current produced by bFGF treatment of PC12 cells are observed for the dihydropyridine sensitive and dihydropyridine/conotoxin insensitive currents. The bFGF-induced increases in barium currents are dependent on tyrosine phosphorylation, since the effects of bFGF are blocked by genistein, a tyrosine kinase inhibitor. This system will ultimately be useful in understanding the signaling pathways that control calcium channel expression in response to growth factors. © 1994 Wiley-Liss, Inc." @default.
• W2115484963 created "2016-06-24" @default.
• W2115484963 creator A5002705400 @default.
• W2115484963 creator A5085174483 @default.
• W2115484963 date "1994-08-01" @default.
• W2115484963 modified "2023-09-27" @default.
• W2115484963 title "Fibroblast growth factor-induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent" @default.
• W2115484963 cites W1490337884 @default.
• W2115484963 cites W1501580127 @default.
• W2115484963 cites W1565303318 @default.
• W2115484963 cites W1572954385 @default.
• W2115484963 cites W1684106405 @default.
• W2115484963 cites W1813092835 @default.
• W2115484963 cites W1833162381 @default.
• W2115484963 cites W1836738800 @default.
• W2115484963 cites W1935382092 @default.
• W2115484963 cites W1942708553 @default.
• W2115484963 cites W1964912566 @default.
• W2115484963 cites W1969445511 @default.
• W2115484963 cites W1970587959 @default.
• W2115484963 cites W1975260251 @default.
• W2115484963 cites W1975495879 @default.
• W2115484963 cites W1975529723 @default.
• W2115484963 cites W1977742032 @default.
• W2115484963 cites W1978798502 @default.
• W2115484963 cites W1979324468 @default.
• W2115484963 cites W1980794835 @default.
• W2115484963 cites W1987619537 @default.
• W2115484963 cites W1997218197 @default.
• W2115484963 cites W2003632139 @default.
• W2115484963 cites W2005662390 @default.
• W2115484963 cites W2009667219 @default.
• W2115484963 cites W2012395442 @default.
• W2115484963 cites W2012760766 @default.
• W2115484963 cites W2019996404 @default.
• W2115484963 cites W2030740718 @default.
• W2115484963 cites W2031452885 @default.
• W2115484963 cites W2057126981 @default.
• W2115484963 cites W2069132844 @default.
• W2115484963 cites W2076950068 @default.
• W2115484963 cites W2080669192 @default.
• W2115484963 cites W2100335264 @default.
• W2115484963 cites W2105727420 @default.
• W2115484963 cites W2121119720 @default.
• W2115484963 cites W2150485450 @default.
• W2115484963 cites W993271046 @default.
• W2115484963 doi "https://doi.org/10.1002/jnr.490380511" @default.
• W2115484963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7815474" @default.
• W2115484963 hasPublicationYear "1994" @default.
• W2115484963 type Work @default.
• W2115484963 sameAs 2115484963 @default.
• W2115484963 citedByCount "29" @default.
• W2115484963 countsByYear W21154849632014 @default.
• W2115484963 countsByYear W21154849632019 @default.
• W2115484963 crossrefType "journal-article" @default.
• W2115484963 hasAuthorship W2115484963A5002705400 @default.
• W2115484963 hasAuthorship W2115484963A5085174483 @default.
• W2115484963 hasConcept C11960822 @default.
• W2115484963 hasConcept C126322002 @default.
• W2115484963 hasConcept C134018914 @default.
• W2115484963 hasConcept C170493617 @default.
• W2115484963 hasConcept C179104552 @default.
• W2115484963 hasConcept C185592680 @default.
• W2115484963 hasConcept C2775960820 @default.
• W2115484963 hasConcept C2777553839 @default.
• W2115484963 hasConcept C2777587049 @default.
• W2115484963 hasConcept C2778423431 @default.
• W2115484963 hasConcept C2781212610 @default.
• W2115484963 hasConcept C42362537 @default.
• W2115484963 hasConcept C519063684 @default.
• W2115484963 hasConcept C542576722 @default.
• W2115484963 hasConcept C62478195 @default.
• W2115484963 hasConcept C71924100 @default.
• W2115484963 hasConcept C74373430 @default.
• W2115484963 hasConcept C85520022 @default.
• W2115484963 hasConcept C86803240 @default.
• W2115484963 hasConcept C95444343 @default.
• W2115484963 hasConceptScore W2115484963C11960822 @default.
• W2115484963 hasConceptScore W2115484963C126322002 @default.
• W2115484963 hasConceptScore W2115484963C134018914 @default.
• W2115484963 hasConceptScore W2115484963C170493617 @default.
• W2115484963 hasConceptScore W2115484963C179104552 @default.
• W2115484963 hasConceptScore W2115484963C185592680 @default.
• W2115484963 hasConceptScore W2115484963C2775960820 @default.
• W2115484963 hasConceptScore W2115484963C2777553839 @default.
• W2115484963 hasConceptScore W2115484963C2777587049 @default.
• W2115484963 hasConceptScore W2115484963C2778423431 @default.
• W2115484963 hasConceptScore W2115484963C2781212610 @default.
• W2115484963 hasConceptScore W2115484963C42362537 @default.
• W2115484963 hasConceptScore W2115484963C519063684 @default.
• W2115484963 hasConceptScore W2115484963C542576722 @default.
• W2115484963 hasConceptScore W2115484963C62478195 @default.
• W2115484963 hasConceptScore W2115484963C71924100 @default.
• W2115484963 hasConceptScore W2115484963C74373430 @default.
• W2115484963 hasConceptScore W2115484963C85520022 @default.
• W2115484963 hasConceptScore W2115484963C86803240 @default.
• W2115484963 hasConceptScore W2115484963C95444343 @default.
• W2115484963 hasIssue "5" @default.

• next