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• W2115486450 endingPage "5780" @default.
• W2115486450 startingPage "5771" @default.
• W2115486450 abstract "Lung cancer encompasses a heterogeneous group of malignancies. Here we discuss how the remarkable diversity of major lung cancer subtypes is manifested in their transforming cell of origin, oncogenic dependencies, phenotypic plasticity, metastatic competence and response to therapy. More specifically, we review the increasing evidence that links this biological heterogeneity to the deregulation of cell lineage-specific pathways and the transcription factors that ultimately control them. As determinants of pulmonary epithelial differentiation, these poorly characterized transcriptional networks may underlie the etiology and biological progression of distinct lung cancers, while providing insight into innovative therapeutic strategies." @default.
• W2115486450 created "2016-06-24" @default.
• W2115486450 creator A5022669224 @default.
• W2115486450 creator A5044110204 @default.
• W2115486450 date "2015-03-30" @default.
• W2115486450 modified "2023-10-16" @default.
• W2115486450 title "Lineage factors and differentiation states in lung cancer progression" @default.
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