FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115486538> ?p ?o ?g. }

• W2115486538 endingPage "967" @default.
• W2115486538 startingPage "963" @default.
• W2115486538 abstract "To evaluate the comparative efficacy and tolerability of topical calcipotriol in the treatment of mild to moderate chronic plaque psoriasis.Quantitative systematic review of randomised controlled trials.6038 patients with plaque psoriasis reported in 37 trials.Mean difference in percentage change in scores on psoriasis area and severity index, and response rate ratios for both patients' and investigators' overall assessments of marked improvement or better. Adverse effects were estimated with the rate ratio, rate difference, and number needed to treat.Calcipotriol was at least as effective as potent topical corticosteroids, calcitriol, short contact dithranol, tacalcitol, coal tar, and combined coal tar 5%, allantoin 2%, and hydrocortisone 0.5%. Calcipotriol caused significantly more skin irritation than potent topical corticosteroids (number needed to treat to harm for irritation 10, 95% confidence interval 6 to 34). Calcipotriol monotherapy also caused more irritation than calcipotriol combined with a potent topical corticosteroid (6, 4 to 8). However, the number needed to treat for dithranol to produce lesional or perilesional irritation was 4 (3 to 5). On average, treating 23 patients with short contact dithranol led to one more patient dropping out of treatment owing to adverse effects than if they were treated with calcipotriol.Calcipotriol is an effective treatment for mild to moderate chronic plaque psoriasis, more so than calcitriol, tacalcitol, coal tar, and short contact dithranol. Only potent topical corticosteroids seem to have comparable efficacy at eight weeks. Although calcipotriol caused more skin irritation than topical corticosteroids this has to be balanced against the potential long term effects of corticosteroids. Skin irritation rarely led to withdrawal of calcipotriol treatment. Longer term comparative trials of calcipotriol versus dithranol and topical corticosteroids are needed to see whether these short term benefits are mirrored by long term outcomes such as duration of remission and improvement in quality of life." @default.
• W2115486538 created "2016-06-24" @default.
• W2115486538 creator A5005808294 @default.
• W2115486538 date "2000-04-08" @default.
• W2115486538 modified "2023-10-18" @default.
• W2115486538 title "Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis" @default.
• W2115486538 cites W1964355112 @default.
• W2115486538 cites W1967029459 @default.
• W2115486538 cites W1977107683 @default.
• W2115486538 cites W1990058265 @default.
• W2115486538 cites W1991230459 @default.
• W2115486538 cites W2026270670 @default.
• W2115486538 cites W2046640549 @default.
• W2115486538 cites W2067327580 @default.
• W2115486538 cites W2107328434 @default.
• W2115486538 cites W2117925995 @default.
• W2115486538 cites W2153113150 @default.
• W2115486538 cites W2161147823 @default.
• W2115486538 cites W2237997722 @default.
• W2115486538 cites W2408780294 @default.
• W2115486538 cites W2415296718 @default.
• W2115486538 doi "https://doi.org/10.1136/bmj.320.7240.963" @default.
• W2115486538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/27334" @default.
• W2115486538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10753146" @default.
• W2115486538 hasPublicationYear "2000" @default.
• W2115486538 type Work @default.
• W2115486538 sameAs 2115486538 @default.
• W2115486538 citedByCount "131" @default.
• W2115486538 countsByYear W21154865382012 @default.
• W2115486538 countsByYear W21154865382013 @default.
• W2115486538 countsByYear W21154865382014 @default.
• W2115486538 countsByYear W21154865382015 @default.
• W2115486538 countsByYear W21154865382016 @default.
• W2115486538 countsByYear W21154865382017 @default.
• W2115486538 countsByYear W21154865382018 @default.
• W2115486538 countsByYear W21154865382019 @default.
• W2115486538 countsByYear W21154865382020 @default.
• W2115486538 countsByYear W21154865382021 @default.
• W2115486538 countsByYear W21154865382022 @default.
• W2115486538 crossrefType "journal-article" @default.
• W2115486538 hasAuthorship W2115486538A5005808294 @default.
• W2115486538 hasBestOaLocation W21154865381 @default.
• W2115486538 hasConcept C124490489 @default.
• W2115486538 hasConcept C126322002 @default.
• W2115486538 hasConcept C142724271 @default.
• W2115486538 hasConcept C16005928 @default.
• W2115486538 hasConcept C197934379 @default.
• W2115486538 hasConcept C203014093 @default.
• W2115486538 hasConcept C204787440 @default.
• W2115486538 hasConcept C27081682 @default.
• W2115486538 hasConcept C2776009542 @default.
• W2115486538 hasConcept C2776079296 @default.
• W2115486538 hasConcept C2777011040 @default.
• W2115486538 hasConcept C2777063393 @default.
• W2115486538 hasConcept C2778375690 @default.
• W2115486538 hasConcept C2780564577 @default.
• W2115486538 hasConcept C2781463552 @default.
• W2115486538 hasConcept C71924100 @default.
• W2115486538 hasConceptScore W2115486538C124490489 @default.
• W2115486538 hasConceptScore W2115486538C126322002 @default.
• W2115486538 hasConceptScore W2115486538C142724271 @default.
• W2115486538 hasConceptScore W2115486538C16005928 @default.
• W2115486538 hasConceptScore W2115486538C197934379 @default.
• W2115486538 hasConceptScore W2115486538C203014093 @default.
• W2115486538 hasConceptScore W2115486538C204787440 @default.
• W2115486538 hasConceptScore W2115486538C27081682 @default.
• W2115486538 hasConceptScore W2115486538C2776009542 @default.
• W2115486538 hasConceptScore W2115486538C2776079296 @default.
• W2115486538 hasConceptScore W2115486538C2777011040 @default.
• W2115486538 hasConceptScore W2115486538C2777063393 @default.
• W2115486538 hasConceptScore W2115486538C2778375690 @default.
• W2115486538 hasConceptScore W2115486538C2780564577 @default.
• W2115486538 hasConceptScore W2115486538C2781463552 @default.
• W2115486538 hasConceptScore W2115486538C71924100 @default.
• W2115486538 hasIssue "7240" @default.
• W2115486538 hasLocation W21154865381 @default.
• W2115486538 hasLocation W21154865382 @default.
• W2115486538 hasLocation W21154865383 @default.
• W2115486538 hasLocation W21154865384 @default.
• W2115486538 hasLocation W21154865385 @default.
• W2115486538 hasOpenAccess W2115486538 @default.
• W2115486538 hasPrimaryLocation W21154865381 @default.
• W2115486538 hasRelatedWork W1966788665 @default.
• W2115486538 hasRelatedWork W1987632618 @default.
• W2115486538 hasRelatedWork W2016404629 @default.
• W2115486538 hasRelatedWork W2030057060 @default.
• W2115486538 hasRelatedWork W2082628671 @default.
• W2115486538 hasRelatedWork W2115486538 @default.
• W2115486538 hasRelatedWork W2135738097 @default.
• W2115486538 hasRelatedWork W2163882073 @default.
• W2115486538 hasRelatedWork W4254680666 @default.
• W2115486538 hasRelatedWork W5615460 @default.
• W2115486538 hasVolume "320" @default.
• W2115486538 isParatext "false" @default.
• W2115486538 isRetracted "false" @default.
• W2115486538 magId "2115486538" @default.
• W2115486538 workType "article" @default.