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• W2115490015 abstract "Prostaglandin E 2 (PGE 2 ), an important mediator of the inflammatory response, acts centrally to elicit sympathetic excitation. PGE 2 acts on at least four E-class prostanoid (EP) receptors known as EP 1 , EP 2 , EP 3 , and EP 4 . Since PGE 2 production within the brain is ubiquitous, the different functions of PGE 2 depend on the expression of these prostanoid receptors in specific brain areas. The type(s) and location(s) of the EP receptors that mediate sympathetic responses to central PGE 2 remain unknown. We examined this question using PGE 2 , the relatively selective EP receptor agonists misoprostol and sulprostone, and the available selective antagonists for EP 1 , EP 3 , and EP 4 . In urethane-anesthetized rats, intracerebroventricular (ICV) administration of PGE 2 , sulprostone or misoprostol increased renal sympathetic nerve activity, blood pressure, and heart rate. These responses were significantly reduced by ICV pretreatment with the EP 3 receptor antagonist; the EP 1 and EP 4 receptor antagonists had little or no effect. ICV PGE 2 or misoprostol increased the discharge of neurons in the hypothalamic paraventricular nucleus (PVN). ICV misoprostol increased the c-Fos immunoreactivity of PVN neurons, an effect that was substantially reduced by the EP 3 receptor antagonist. Real-time PCR detected EP 3 receptor mRNA in PVN, and immunohistochemical studies revealed sparsely distributed EP 3 receptors localized in GABAergic terminals and on a few PVN neurons. Direct bilateral PVN microinjections of PGE 2 or sulprostone elicited sympathoexcitatory responses that were significantly reduced by the EP 3 receptor antagonist. These data suggest that EP 3 receptors mediate the central excitatory effects of PGE 2 on PVN neurons and sympathetic discharge." @default.
• W2115490015 created "2016-06-24" @default.
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• W2115490015 date "2011-10-01" @default.
• W2115490015 modified "2023-09-24" @default.
• W2115490015 title "EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation" @default.
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• W2115490015 doi "https://doi.org/10.1152/ajpheart.00262.2011" @default.
• W2115490015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3197370" @default.
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