FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115513246> ?p ?o ?g. }

• W2115513246 abstract "Pilose antler polypeptides (PAP) have been reported to promote chondrocyte proliferation. However, the underlying mechanism remains unclear. The present study was to investigate the effects of PAP on the proliferation of chondrocytes and its underlying mechanism.Chondrocytes isolated from the knee of Zealand white rabbits were cultured. The second generation chondrocytes were collected and identified using safranin-O staining. The chondrocytes were divided into the following 4 groups including serum-free, PAP, genistein (an inhibitor of tyrosine kinases), and PAP plus genistein group. Cell viability was analyzed using the MTT assay. The cell cycle distribution of the chondrocytes was analyzed by flow cytometry. The expression levels of cyclin A was detected using immunocytochemical staining.No significant difference was observed between serum-free and genistein group. Treatment of the cultures with PAP produced a significant dose-dependent increase in cell viability, the percentage proportion of chondrocytes in the S phase and Cyclin A expression as well. However, the promoting effect of PAP on chondrocyte proliferation were dose-dependently inhibited by genistein, whereas genistein alone had no effect on proliferation of isolated chondrocytes.The data demonstrate that PAP promotes chondrocyte proliferation with the increased cell number, percentage proportion of chondrocytes in S phase and expression of protein cyclin A via the TK signaling pathway." @default.
• W2115513246 created "2016-06-24" @default.
• W2115513246 creator A5005449938 @default.
• W2115513246 creator A5009364229 @default.
• W2115513246 creator A5066716873 @default.
• W2115513246 creator A5067385943 @default.
• W2115513246 creator A5078924802 @default.
• W2115513246 date "2011-11-10" @default.
• W2115513246 modified "2023-10-14" @default.
• W2115513246 title "Pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway" @default.
• W2115513246 cites W1656644300 @default.
• W2115513246 cites W1988981981 @default.
• W2115513246 cites W2007094424 @default.
• W2115513246 cites W2018650916 @default.
• W2115513246 cites W2065844116 @default.
• W2115513246 cites W2074842192 @default.
• W2115513246 cites W2129330575 @default.
• W2115513246 doi "https://doi.org/10.1186/1745-6673-6-27" @default.
• W2115513246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3226629" @default.
• W2115513246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22074291" @default.
• W2115513246 hasPublicationYear "2011" @default.
• W2115513246 type Work @default.
• W2115513246 sameAs 2115513246 @default.
• W2115513246 citedByCount "19" @default.
• W2115513246 countsByYear W21155132462014 @default.
• W2115513246 countsByYear W21155132462016 @default.
• W2115513246 countsByYear W21155132462017 @default.
• W2115513246 countsByYear W21155132462018 @default.
• W2115513246 countsByYear W21155132462019 @default.
• W2115513246 countsByYear W21155132462020 @default.
• W2115513246 countsByYear W21155132462021 @default.
• W2115513246 countsByYear W21155132462022 @default.
• W2115513246 countsByYear W21155132462023 @default.
• W2115513246 crossrefType "journal-article" @default.
• W2115513246 hasAuthorship W2115513246A5005449938 @default.
• W2115513246 hasAuthorship W2115513246A5009364229 @default.
• W2115513246 hasAuthorship W2115513246A5066716873 @default.
• W2115513246 hasAuthorship W2115513246A5067385943 @default.
• W2115513246 hasAuthorship W2115513246A5078924802 @default.
• W2115513246 hasBestOaLocation W21155132461 @default.
• W2115513246 hasConcept C105702510 @default.
• W2115513246 hasConcept C120089663 @default.
• W2115513246 hasConcept C121608353 @default.
• W2115513246 hasConcept C126322002 @default.
• W2115513246 hasConcept C1491633281 @default.
• W2115513246 hasConcept C153911025 @default.
• W2115513246 hasConcept C199835354 @default.
• W2115513246 hasConcept C2778298627 @default.
• W2115513246 hasConcept C2780550940 @default.
• W2115513246 hasConcept C2780783641 @default.
• W2115513246 hasConcept C2781403057 @default.
• W2115513246 hasConcept C2781403221 @default.
• W2115513246 hasConcept C29537977 @default.
• W2115513246 hasConcept C53227056 @default.
• W2115513246 hasConcept C55493867 @default.
• W2115513246 hasConcept C62112901 @default.
• W2115513246 hasConcept C71924100 @default.
• W2115513246 hasConcept C86803240 @default.
• W2115513246 hasConcept C95444343 @default.
• W2115513246 hasConceptScore W2115513246C105702510 @default.
• W2115513246 hasConceptScore W2115513246C120089663 @default.
• W2115513246 hasConceptScore W2115513246C121608353 @default.
• W2115513246 hasConceptScore W2115513246C126322002 @default.
• W2115513246 hasConceptScore W2115513246C1491633281 @default.
• W2115513246 hasConceptScore W2115513246C153911025 @default.
• W2115513246 hasConceptScore W2115513246C199835354 @default.
• W2115513246 hasConceptScore W2115513246C2778298627 @default.
• W2115513246 hasConceptScore W2115513246C2780550940 @default.
• W2115513246 hasConceptScore W2115513246C2780783641 @default.
• W2115513246 hasConceptScore W2115513246C2781403057 @default.
• W2115513246 hasConceptScore W2115513246C2781403221 @default.
• W2115513246 hasConceptScore W2115513246C29537977 @default.
• W2115513246 hasConceptScore W2115513246C53227056 @default.
• W2115513246 hasConceptScore W2115513246C55493867 @default.
• W2115513246 hasConceptScore W2115513246C62112901 @default.
• W2115513246 hasConceptScore W2115513246C71924100 @default.
• W2115513246 hasConceptScore W2115513246C86803240 @default.
• W2115513246 hasConceptScore W2115513246C95444343 @default.
• W2115513246 hasIssue "1" @default.
• W2115513246 hasLocation W21155132461 @default.
• W2115513246 hasLocation W21155132462 @default.
• W2115513246 hasLocation W21155132463 @default.
• W2115513246 hasLocation W21155132464 @default.
• W2115513246 hasOpenAccess W2115513246 @default.
• W2115513246 hasPrimaryLocation W21155132461 @default.
• W2115513246 hasRelatedWork W1996281275 @default.
• W2115513246 hasRelatedWork W2115513246 @default.
• W2115513246 hasRelatedWork W2139803439 @default.
• W2115513246 hasRelatedWork W2351410834 @default.
• W2115513246 hasRelatedWork W2352632797 @default.
• W2115513246 hasRelatedWork W2358430638 @default.
• W2115513246 hasRelatedWork W2365244765 @default.
• W2115513246 hasRelatedWork W2373021097 @default.
• W2115513246 hasRelatedWork W4295787401 @default.
• W2115513246 hasRelatedWork W83581725 @default.
• W2115513246 hasVolume "6" @default.
• W2115513246 isParatext "false" @default.
• W2115513246 isRetracted "false" @default.
• W2115513246 magId "2115513246" @default.
• W2115513246 workType "article" @default.