Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115517178> ?p ?o ?g. }
- W2115517178 endingPage "417" @default.
- W2115517178 startingPage "408" @default.
- W2115517178 abstract "Background aims Pancreatic cancer, sometimes called a ‘silent killer’, is one of the most aggressive human malignancies, with a very poor prognosis. It is the fourth leading cause of cancer-related morbidity and mortality in the USA. Methods A mouse peritoneal model was used to test the ability of unengineered rat umbilical cord matrix-derived stem cells (UCMSC) to control growth of pancreatic cancer. In vivo results were supported by various in vitro assays, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), direct cell count, [3H]thymidine uptake and soft agar colony assays. Results Co-culture of rat UCMSC with PAN02 murine pancreatic carcinoma cells (UCMSC:PAN02, 1:6 and 1:3) caused G0/G1 arrest and significantly attenuated the proliferation of PAN02 tumor cells, as monitored by MTT assay, direct cell counts and [3H]thymidine uptake assay. Rat UCMSC also significantly reduced PAN02 colony size and number, as measured by soft agar colony assay. The in vivo mouse studies showed that rat UCMSC treatment significantly decreased the peritoneal PAN02 tumor burden 3 weeks after tumor transplantation and increased mouse survival time. Histologic study revealed that intraperitoneally administered rat UCMSC survived for at least 3 weeks, and the majority were found near or inside the tumor. Conclusions These results indicate that naive rat UCMSC alone remarkably attenuate the growth of pancreatic carcinoma cells in vitro and in a mouse peritoneal model. This implies that UCMSC could be a potential tool for targeted cytotherapy for pancreatic cancer." @default.
- W2115517178 created "2016-06-24" @default.
- W2115517178 creator A5001893065 @default.
- W2115517178 creator A5013108076 @default.
- W2115517178 creator A5067644687 @default.
- W2115517178 creator A5074226912 @default.
- W2115517178 creator A5090975463 @default.
- W2115517178 date "2010-01-01" @default.
- W2115517178 modified "2023-10-17" @default.
- W2115517178 title "Cytotherapy with naive rat umbilical cord matrix stem cells significantly attenuates growth of murine pancreatic cancer cells and increases survival in syngeneic mice" @default.
- W2115517178 cites W1969644104 @default.
- W2115517178 cites W1980441719 @default.
- W2115517178 cites W1992733371 @default.
- W2115517178 cites W2007293466 @default.
- W2115517178 cites W2008201857 @default.
- W2115517178 cites W2014231393 @default.
- W2115517178 cites W2021482268 @default.
- W2115517178 cites W2031365339 @default.
- W2115517178 cites W2036966078 @default.
- W2115517178 cites W2054235928 @default.
- W2115517178 cites W2058256440 @default.
- W2115517178 cites W206590346 @default.
- W2115517178 cites W2081026244 @default.
- W2115517178 cites W2099023480 @default.
- W2115517178 cites W2101526099 @default.
- W2115517178 cites W2101995865 @default.
- W2115517178 cites W2106360889 @default.
- W2115517178 cites W2106505027 @default.
- W2115517178 cites W2125793635 @default.
- W2115517178 cites W2127734192 @default.
- W2115517178 cites W2135212691 @default.
- W2115517178 cites W2140073859 @default.
- W2115517178 cites W2141433020 @default.
- W2115517178 cites W2141815918 @default.
- W2115517178 cites W2143022774 @default.
- W2115517178 cites W2148278891 @default.
- W2115517178 cites W2156323704 @default.
- W2115517178 cites W2163234891 @default.
- W2115517178 cites W4213229297 @default.
- W2115517178 cites W4231031590 @default.
- W2115517178 cites W4247785462 @default.
- W2115517178 cites W4292165628 @default.
- W2115517178 doi "https://doi.org/10.3109/14653240903548194" @default.
- W2115517178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896419" @default.
- W2115517178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20345214" @default.
- W2115517178 hasPublicationYear "2010" @default.
- W2115517178 type Work @default.
- W2115517178 sameAs 2115517178 @default.
- W2115517178 citedByCount "40" @default.
- W2115517178 countsByYear W21155171782012 @default.
- W2115517178 countsByYear W21155171782013 @default.
- W2115517178 countsByYear W21155171782014 @default.
- W2115517178 countsByYear W21155171782015 @default.
- W2115517178 countsByYear W21155171782016 @default.
- W2115517178 countsByYear W21155171782017 @default.
- W2115517178 countsByYear W21155171782018 @default.
- W2115517178 countsByYear W21155171782019 @default.
- W2115517178 countsByYear W21155171782020 @default.
- W2115517178 countsByYear W21155171782021 @default.
- W2115517178 countsByYear W21155171782022 @default.
- W2115517178 countsByYear W21155171782023 @default.
- W2115517178 crossrefType "journal-article" @default.
- W2115517178 hasAuthorship W2115517178A5001893065 @default.
- W2115517178 hasAuthorship W2115517178A5013108076 @default.
- W2115517178 hasAuthorship W2115517178A5067644687 @default.
- W2115517178 hasAuthorship W2115517178A5074226912 @default.
- W2115517178 hasAuthorship W2115517178A5090975463 @default.
- W2115517178 hasBestOaLocation W21155171782 @default.
- W2115517178 hasConcept C121608353 @default.
- W2115517178 hasConcept C126322002 @default.
- W2115517178 hasConcept C142724271 @default.
- W2115517178 hasConcept C150903083 @default.
- W2115517178 hasConcept C202751555 @default.
- W2115517178 hasConcept C203014093 @default.
- W2115517178 hasConcept C207001950 @default.
- W2115517178 hasConcept C2780210213 @default.
- W2115517178 hasConcept C2780783641 @default.
- W2115517178 hasConcept C2911091166 @default.
- W2115517178 hasConcept C502942594 @default.
- W2115517178 hasConcept C55493867 @default.
- W2115517178 hasConcept C71924100 @default.
- W2115517178 hasConcept C86803240 @default.
- W2115517178 hasConceptScore W2115517178C121608353 @default.
- W2115517178 hasConceptScore W2115517178C126322002 @default.
- W2115517178 hasConceptScore W2115517178C142724271 @default.
- W2115517178 hasConceptScore W2115517178C150903083 @default.
- W2115517178 hasConceptScore W2115517178C202751555 @default.
- W2115517178 hasConceptScore W2115517178C203014093 @default.
- W2115517178 hasConceptScore W2115517178C207001950 @default.
- W2115517178 hasConceptScore W2115517178C2780210213 @default.
- W2115517178 hasConceptScore W2115517178C2780783641 @default.
- W2115517178 hasConceptScore W2115517178C2911091166 @default.
- W2115517178 hasConceptScore W2115517178C502942594 @default.
- W2115517178 hasConceptScore W2115517178C55493867 @default.
- W2115517178 hasConceptScore W2115517178C71924100 @default.
- W2115517178 hasConceptScore W2115517178C86803240 @default.
- W2115517178 hasIssue "3" @default.
- W2115517178 hasLocation W21155171781 @default.