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- W2115520939 abstract "Retrotransposons constitute a major source of genetic variation, and somatic retrotransposon insertions have been reported in cancer. Here, we applied TranspoSeq, a computational framework that identifies retrotransposon insertions from sequencing data, to whole genomes from 200 tumor/normal pairs across 11 tumor types as part of The Cancer Genome Atlas (TCGA) Pan-Cancer Project. In addition to novel germline polymorphisms, we find 810 somatic retrotransposon insertions primarily in lung squamous, head and neck, colorectal, and endometrial carcinomas. Many somatic retrotransposon insertions occur in known cancer genes. We find that high somatic retrotransposition rates in tumors are associated with high rates of genomic rearrangement and somatic mutation. Finally, we developed TranspoSeq-Exome to interrogate an additional 767 tumor samples with hybrid-capture exome data and discovered 35 novel somatic retrotransposon insertions into exonic regions, including an insertion into an exon of the PTEN tumor suppressor gene. The results of this large-scale, comprehensive analysis of retrotransposon movement across tumor types suggest that somatic retrotransposon insertions may represent an important class of structural variation in cancer." @default.
- W2115520939 created "2016-06-24" @default.
- W2115520939 creator A5001392592 @default.
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- W2115520939 date "2014-05-13" @default.
- W2115520939 modified "2023-10-14" @default.
- W2115520939 title "Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing" @default.
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- W2115520939 doi "https://doi.org/10.1101/gr.163659.113" @default.
- W2115520939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4079962" @default.
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