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- W2115554334 abstract "The ribosome has a distinct lateral protuberance called the stalk; in eukaryotes it is formed by the acidic ribosomal P-proteins which are organized as a pentameric entity described as P0-(P1-P2)(2). Bilateral interactions between P0 and P1/P2 proteins have been studied extensively, however, the region on P0 responsible for the binding of P1/P2 proteins has not been precisely defined. Here we report a study which takes the current knowledge of the P0 - P1/P2 protein interaction beyond the recently published information. Using truncated forms of P0 protein and several in vitro and in vivo approaches, we have defined the region between positions 199 and 258 as the P0 protein fragment responsible for the binding of P1/P2 proteins in the yeast Saccharomyces cerevisiae. We show two short amino acid regions of P0 protein located at positions 199-230 and 231-258, to be responsible for independent binding of two dimers, P1A-P2B and P1B-P2A respectively. In addition, two elements, the sequence spanning amino acids 199-230 and the P1A-P2B dimer were found to be essential for stalk formation, indicating that this process is dependent on a balance between the P1A-P2B dimer and the P0 protein." @default.
- W2115554334 created "2016-06-24" @default.
- W2115554334 creator A5004651925 @default.
- W2115554334 creator A5017715895 @default.
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- W2115554334 creator A5045638207 @default.
- W2115554334 creator A5051257478 @default.
- W2115554334 creator A5081141506 @default.
- W2115554334 date "2006-03-03" @default.
- W2115554334 modified "2023-10-16" @default.
- W2115554334 title "Yeast ribosomal P0 protein has two separate binding sites for P1/P2 proteins" @default.
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- W2115554334 doi "https://doi.org/10.1111/j.1365-2958.2006.05117.x" @default.
- W2115554334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16573688" @default.
- W2115554334 hasPublicationYear "2006" @default.
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