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• W2115563352 abstract "Funding sources: none. Conflicts of interest: none declared. Dear Editor, Alitretinoin (9‐cis‐retinoic acid) is a synthetic vitamin A derivative with immunomodulatory and anti‐inflammatory activity recently licensed as a treatment for refractory chronic hand eczema.1 Here, we report the successful use of oral alitretinoin in two women of childbearing age with Darier's disease (DD). DD (OMIM 124200) is an autosomal dominant disorder of keratinization characterized by multiple discrete or confluent warty papules and plaques in seborrhoeic areas, palmoplantar pits, and distinctive nail dystrophy2 of teenage or adult onset. Histologically, DD lesions show suprabasal acantholysis and dyskeratosis, and ultrastructurally lesions show reduced numbers of desmosomes, disruption of desmosomal complexes and perinuclear aggregates of keratin filaments.3 4 A large spectrum of heterozygous mutations in ATP2A2, encoding the sarco/endoplasmic reticulum calcium ATPase isoform 2 (SERCA2) are responsible for DD. Calcium pumps of the SERCA family have a key role in intracellular signalling by regulating cell–cell adhesion and epidermal differentiation.3 5 6" @default.
• W2115563352 created "2016-06-24" @default.
• W2115563352 creator A5035773514 @default.
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• W2115563352 date "2013-08-30" @default.
• W2115563352 modified "2023-10-14" @default.
• W2115563352 title "Successful treatment with oral alitretinoin in women of childbearing potential with Darier's disease" @default.
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• W2115563352 doi "https://doi.org/10.1111/bjd.12348" @default.
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