FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115570637> ?p ?o ?g. }

• W2115570637 endingPage "455" @default.
• W2115570637 startingPage "445" @default.
• W2115570637 abstract "Twenty-four patients (three male) with Cushing's disease, aged between 11 and 67 years, were treated with low-dose external pituitary irradiation (20 Gy in eight fractions over 10–12 days) and followed for between 13 and 171 months (median 93 months). Eleven patients (46%) went into remission 4–36 months after irradiation, but five subsequently relapsed. Two of these received no further active treatment, one underwent successful pituitary surgery, one underwent a second course of low-dose external irradiation (as yet unsuccessful) and one has been treated with metyrapone for a total of 75 months. One of the 13 patients who did not respond received a further course of low-dose pituitary irradiation with prompt remission and two have received metyrapone for 41 months and 15 years without ill effect. One patient died from cerebrovascular disease. The remaining nine patients underwent bilateral adrenalectomy (one after unsuccessful pituitary surgery) with rapid resolution of hypercortisolism. Five of these patients have developed hyperpigmentation and elevated ACTH levels (range 505–1150 ng/1). A pituitary microadenoma has been demonstrated on CT scan in three and successfully removed by microadenomectomy. In the present series, the low incidence of radiation-induced hypopituitarism and absence of other complications attributable to radiotherapy suggest that low-dose pituitary irradiation may be a useful treatment option in selected patients. However, long-term follow-up has demonstrated a high relapse rate and failure to prevent Nelson's syndrome in adrenalectomized patients, indicating that it should not be used as primary treatment in preference to selective adenomectomy." @default.
• W2115570637 created "2016-06-24" @default.
• W2115570637 creator A5007124755 @default.
• W2115570637 creator A5009497247 @default.
• W2115570637 creator A5054004237 @default.
• W2115570637 creator A5062187545 @default.
• W2115570637 creator A5088689253 @default.
• W2115570637 date "1990-10-01" @default.
• W2115570637 modified "2023-09-24" @default.
• W2115570637 title "LONG-TERM FOLLOW-UP OF LOW-DOSE EXTERNAL PITUITARY IRRADIATION FOR CUSHING'S DISEASE" @default.
• W2115570637 cites W1964198576 @default.
• W2115570637 cites W1982179547 @default.
• W2115570637 cites W1996997276 @default.
• W2115570637 cites W2004360545 @default.
• W2115570637 cites W2010744138 @default.
• W2115570637 cites W2012852341 @default.
• W2115570637 cites W2013574005 @default.
• W2115570637 cites W2016736324 @default.
• W2115570637 cites W2018299169 @default.
• W2115570637 cites W2018932366 @default.
• W2115570637 cites W2024295646 @default.
• W2115570637 cites W2025784270 @default.
• W2115570637 cites W2027129545 @default.
• W2115570637 cites W2048768386 @default.
• W2115570637 cites W2050945708 @default.
• W2115570637 cites W2051302106 @default.
• W2115570637 cites W2052888200 @default.
• W2115570637 cites W2057537176 @default.
• W2115570637 cites W2066862078 @default.
• W2115570637 cites W2071249891 @default.
• W2115570637 cites W2073005838 @default.
• W2115570637 cites W2073869734 @default.
• W2115570637 cites W2089877536 @default.
• W2115570637 cites W2092312381 @default.
• W2115570637 cites W2107886281 @default.
• W2115570637 cites W2114420323 @default.
• W2115570637 cites W2139673335 @default.
• W2115570637 cites W2162929948 @default.
• W2115570637 cites W2166446873 @default.
• W2115570637 cites W2168382553 @default.
• W2115570637 cites W2177354678 @default.
• W2115570637 cites W2318130783 @default.
• W2115570637 cites W2338100252 @default.
• W2115570637 doi "https://doi.org/10.1111/j.1365-2265.1990.tb03883.x" @default.
• W2115570637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2225489" @default.
• W2115570637 hasPublicationYear "1990" @default.
• W2115570637 type Work @default.
• W2115570637 sameAs 2115570637 @default.
• W2115570637 citedByCount "99" @default.
• W2115570637 countsByYear W21155706372012 @default.
• W2115570637 countsByYear W21155706372013 @default.
• W2115570637 countsByYear W21155706372014 @default.
• W2115570637 countsByYear W21155706372015 @default.
• W2115570637 countsByYear W21155706372016 @default.
• W2115570637 countsByYear W21155706372017 @default.
• W2115570637 countsByYear W21155706372018 @default.
• W2115570637 countsByYear W21155706372019 @default.
• W2115570637 countsByYear W21155706372020 @default.
• W2115570637 countsByYear W21155706372021 @default.
• W2115570637 countsByYear W21155706372022 @default.
• W2115570637 crossrefType "journal-article" @default.
• W2115570637 hasAuthorship W2115570637A5007124755 @default.
• W2115570637 hasAuthorship W2115570637A5009497247 @default.
• W2115570637 hasAuthorship W2115570637A5054004237 @default.
• W2115570637 hasAuthorship W2115570637A5062187545 @default.
• W2115570637 hasAuthorship W2115570637A5088689253 @default.
• W2115570637 hasConcept C120665830 @default.
• W2115570637 hasConcept C121332964 @default.
• W2115570637 hasConcept C126322002 @default.
• W2115570637 hasConcept C141071460 @default.
• W2115570637 hasConcept C2776719974 @default.
• W2115570637 hasConcept C2776810848 @default.
• W2115570637 hasConcept C2778491484 @default.
• W2115570637 hasConcept C2779134260 @default.
• W2115570637 hasConcept C2780087391 @default.
• W2115570637 hasConcept C509974204 @default.
• W2115570637 hasConcept C61511704 @default.
• W2115570637 hasConcept C71924100 @default.
• W2115570637 hasConcept C90924648 @default.
• W2115570637 hasConceptScore W2115570637C120665830 @default.
• W2115570637 hasConceptScore W2115570637C121332964 @default.
• W2115570637 hasConceptScore W2115570637C126322002 @default.
• W2115570637 hasConceptScore W2115570637C141071460 @default.
• W2115570637 hasConceptScore W2115570637C2776719974 @default.
• W2115570637 hasConceptScore W2115570637C2776810848 @default.
• W2115570637 hasConceptScore W2115570637C2778491484 @default.
• W2115570637 hasConceptScore W2115570637C2779134260 @default.
• W2115570637 hasConceptScore W2115570637C2780087391 @default.
• W2115570637 hasConceptScore W2115570637C509974204 @default.
• W2115570637 hasConceptScore W2115570637C61511704 @default.
• W2115570637 hasConceptScore W2115570637C71924100 @default.
• W2115570637 hasConceptScore W2115570637C90924648 @default.
• W2115570637 hasIssue "4" @default.
• W2115570637 hasLocation W21155706371 @default.
• W2115570637 hasLocation W21155706372 @default.
• W2115570637 hasOpenAccess W2115570637 @default.
• W2115570637 hasPrimaryLocation W21155706371 @default.
• W2115570637 hasRelatedWork W1964671363 @default.

• next