FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115572195> ?p ?o ?g. }

• W2115572195 endingPage "196" @default.
• W2115572195 startingPage "186" @default.
• W2115572195 abstract "Transporter-mediated absorption, secretion, and reabsorption of chemicals are increasingly recognized as important determinants in the biological activities of many xenobiotics. In recent years, the rapid progress in generating and characterizing mice with targeted deletion of transporters has greatly increased our knowledge of the functions of transporters in the pharmacokinetics/toxicokinetics of xenobiotics. In this introduction, we focus on functions of transporters learned from experiments on knockout mice as well as humans and rodents with natural mutations of these transporters. We limit our discussion to transporters that either directly transport xenobiotics or are important in biliary excretion or cellular defenses, namely multidrug resistance, multidrug resistance–associated proteins, breast cancer resistance protein, organic anion transporting polypeptides, organic anion transporters, organic cation transporters, nucleoside transporters, peptide transporters, bile acid transporters, cholesterol transporters, and phospholipid transporters, as well as metal transporters. Efflux transporters in intestine, liver, kidney, brain, testes, and placenta can efflux xenobiotics out of cells and serve as barriers against the entrance of xenobiotics into cells, whereas many xenobiotics enter the biological system via uptake transporters. The functional importance of a given transporter in each tissue depends on its substrate specificity, expression level, and the presence/absence of other transporters with overlapping substrate preferences. Nevertheless, a transporter may affect a tissue independent of its local expression by altering systemic metabolism. Further studies on the gene regulation and function of transporters, as well as the interrelationship between transporters and phase I/II xenobiotic-metabolizing enzymes, will provide a complete framework for developing novel strategies to protect us from xenobiotic insults." @default.
• W2115572195 created "2016-06-24" @default.
• W2115572195 creator A5068046399 @default.
• W2115572195 creator A5076743166 @default.
• W2115572195 date "2007-08-13" @default.
• W2115572195 modified "2023-10-17" @default.
• W2115572195 title "Xenobiotic Transporters: Ascribing Function from Gene Knockout and Mutation Studies" @default.
• W2115572195 cites W1549922730 @default.
• W2115572195 cites W1970359870 @default.
• W2115572195 cites W1971139086 @default.
• W2115572195 cites W1971901938 @default.
• W2115572195 cites W1977634450 @default.
• W2115572195 cites W1978017146 @default.
• W2115572195 cites W1978086567 @default.
• W2115572195 cites W1980653400 @default.
• W2115572195 cites W1985625224 @default.
• W2115572195 cites W1989086831 @default.
• W2115572195 cites W1993418630 @default.
• W2115572195 cites W1994784815 @default.
• W2115572195 cites W1996321551 @default.
• W2115572195 cites W2003517015 @default.
• W2115572195 cites W2007084427 @default.
• W2115572195 cites W2013271972 @default.
• W2115572195 cites W2018582379 @default.
• W2115572195 cites W2021018323 @default.
• W2115572195 cites W2022749477 @default.
• W2115572195 cites W2022844399 @default.
• W2115572195 cites W2023471754 @default.
• W2115572195 cites W2034886511 @default.
• W2115572195 cites W2037387044 @default.
• W2115572195 cites W2045543458 @default.
• W2115572195 cites W2052992240 @default.
• W2115572195 cites W2055437362 @default.
• W2115572195 cites W2059629870 @default.
• W2115572195 cites W2076194172 @default.
• W2115572195 cites W2077122729 @default.
• W2115572195 cites W2078524075 @default.
• W2115572195 cites W2084487597 @default.
• W2115572195 cites W2085131512 @default.
• W2115572195 cites W2086609663 @default.
• W2115572195 cites W2093467902 @default.
• W2115572195 cites W2094110689 @default.
• W2115572195 cites W2096136187 @default.
• W2115572195 cites W2098029865 @default.
• W2115572195 cites W2098447911 @default.
• W2115572195 cites W2101686121 @default.
• W2115572195 cites W2101812744 @default.
• W2115572195 cites W2102542060 @default.
• W2115572195 cites W2102611661 @default.
• W2115572195 cites W2103726108 @default.
• W2115572195 cites W2103970958 @default.
• W2115572195 cites W2104711019 @default.
• W2115572195 cites W2106762675 @default.
• W2115572195 cites W2108293406 @default.
• W2115572195 cites W2108686166 @default.
• W2115572195 cites W2112107674 @default.
• W2115572195 cites W2113581854 @default.
• W2115572195 cites W2113613489 @default.
• W2115572195 cites W2116203135 @default.
• W2115572195 cites W2116643925 @default.
• W2115572195 cites W2118667947 @default.
• W2115572195 cites W2120369408 @default.
• W2115572195 cites W2123936150 @default.
• W2115572195 cites W2126698884 @default.
• W2115572195 cites W2127955110 @default.
• W2115572195 cites W2131339869 @default.
• W2115572195 cites W2134606187 @default.
• W2115572195 cites W2136564762 @default.
• W2115572195 cites W2140677989 @default.
• W2115572195 cites W2147286697 @default.
• W2115572195 cites W2149786401 @default.
• W2115572195 cites W2151444334 @default.
• W2115572195 cites W2153338237 @default.
• W2115572195 cites W2156094398 @default.
• W2115572195 cites W2159939387 @default.
• W2115572195 cites W2160034626 @default.
• W2115572195 cites W2160320288 @default.
• W2115572195 cites W2161092181 @default.
• W2115572195 cites W2161215121 @default.
• W2115572195 cites W2162406652 @default.
• W2115572195 cites W2164232957 @default.
• W2115572195 cites W2166153381 @default.
• W2115572195 cites W2171073522 @default.
• W2115572195 cites W2315418372 @default.
• W2115572195 cites W4247418557 @default.
• W2115572195 doi "https://doi.org/10.1093/toxsci/kfm214" @default.
• W2115572195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17698509" @default.
• W2115572195 hasPublicationYear "2007" @default.
• W2115572195 type Work @default.
• W2115572195 sameAs 2115572195 @default.
• W2115572195 citedByCount "113" @default.
• W2115572195 countsByYear W21155721952012 @default.
• W2115572195 countsByYear W21155721952013 @default.
• W2115572195 countsByYear W21155721952014 @default.
• W2115572195 countsByYear W21155721952015 @default.
• W2115572195 countsByYear W21155721952016 @default.
• W2115572195 countsByYear W21155721952017 @default.
• W2115572195 countsByYear W21155721952018 @default.

• next