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- W2115573876 abstract "Activation of the ARF–p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF–p53 pathway is dysfunctional in a high proportion of human cancers. The regulation of the ARF–p53 signaling pathway has not yet been well characterized. In this study polyoma virus (Py) is used as a tool to better define the ARF–p53 signaling pathway. Py middle T-antigen (PyMT) induces ARF, which consequently up-regulates p53. We show that Py small T-antigen (PyST) blocks ARF-mediated activation of p53. This inhibition requires the small T-antigen PP2A-interacting domain. Our results reveal a previously unrecognized role of PP2A in the modulation of the ARF–p53 tumor suppressor pathway." @default.
- W2115573876 created "2016-06-24" @default.
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- W2115573876 date "2004-09-21" @default.
- W2115573876 modified "2023-10-03" @default.
- W2115573876 title "Role for PP2A in ARF signaling to p53" @default.
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- W2115573876 doi "https://doi.org/10.1073/pnas.0405533101" @default.
- W2115573876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/521121" @default.
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- W2115573876 hasPublicationYear "2004" @default.
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