Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115575892> ?p ?o ?g. }
- W2115575892 endingPage "1428" @default.
- W2115575892 startingPage "1418" @default.
- W2115575892 abstract "Spinal muscular atrophy (SMA) is a genetic disorder caused by the deletion of the survival motor neuron 1 (SMN1) gene that leads to loss of motor neurons in the spinal cord. Although motor neurons are selectively lost during SMA pathology, selective replacement of SMN in motor neurons does not lead to full rescue in mouse models. Due to the ubiquitous expression of SMN, it is likely that other cell types besides motor neurons are affected by its disruption and therefore may contribute to disease pathology. Here we show that astrocytes in SMAΔ7 mouse spinal cord and from SMA-induced pluripotent stem cells exhibit morphological and cellular changes indicative of activation before overt motor neuron loss. Furthermore, our in vitro studies show mis-regulation of basal calcium and decreased response to adenosine triphosphate stimulation indicating abnormal astrocyte function. Together, for the first time, these data show early disruptions in astrocytes that may contribute to SMA disease pathology." @default.
- W2115575892 created "2016-06-24" @default.
- W2115575892 creator A5028617616 @default.
- W2115575892 creator A5031613698 @default.
- W2115575892 creator A5046504637 @default.
- W2115575892 creator A5074274519 @default.
- W2115575892 creator A5088325043 @default.
- W2115575892 creator A5091428631 @default.
- W2115575892 date "2013-07-10" @default.
- W2115575892 modified "2023-10-06" @default.
- W2115575892 title "Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production" @default.
- W2115575892 cites W1497938915 @default.
- W2115575892 cites W1554872850 @default.
- W2115575892 cites W1880364852 @default.
- W2115575892 cites W1895507670 @default.
- W2115575892 cites W1965676841 @default.
- W2115575892 cites W1966568307 @default.
- W2115575892 cites W1967814428 @default.
- W2115575892 cites W1974226216 @default.
- W2115575892 cites W1976849281 @default.
- W2115575892 cites W1978120353 @default.
- W2115575892 cites W1980477780 @default.
- W2115575892 cites W1980922145 @default.
- W2115575892 cites W1984680116 @default.
- W2115575892 cites W1985933922 @default.
- W2115575892 cites W1987687980 @default.
- W2115575892 cites W1990007003 @default.
- W2115575892 cites W1990414934 @default.
- W2115575892 cites W1993064034 @default.
- W2115575892 cites W1993374742 @default.
- W2115575892 cites W1994142333 @default.
- W2115575892 cites W1994452959 @default.
- W2115575892 cites W1994893435 @default.
- W2115575892 cites W1998432972 @default.
- W2115575892 cites W2002112358 @default.
- W2115575892 cites W2002912370 @default.
- W2115575892 cites W2003963645 @default.
- W2115575892 cites W2012851706 @default.
- W2115575892 cites W2019293837 @default.
- W2115575892 cites W2019638822 @default.
- W2115575892 cites W2021416323 @default.
- W2115575892 cites W2026955814 @default.
- W2115575892 cites W2027616725 @default.
- W2115575892 cites W2029906820 @default.
- W2115575892 cites W2031391621 @default.
- W2115575892 cites W2032985825 @default.
- W2115575892 cites W2033397150 @default.
- W2115575892 cites W2044804580 @default.
- W2115575892 cites W2045117117 @default.
- W2115575892 cites W2047268435 @default.
- W2115575892 cites W2049486349 @default.
- W2115575892 cites W2050034509 @default.
- W2115575892 cites W2058696184 @default.
- W2115575892 cites W2066058435 @default.
- W2115575892 cites W2070086105 @default.
- W2115575892 cites W2085246606 @default.
- W2115575892 cites W2086259312 @default.
- W2115575892 cites W2088318073 @default.
- W2115575892 cites W2088820444 @default.
- W2115575892 cites W2091223560 @default.
- W2115575892 cites W2096012750 @default.
- W2115575892 cites W2101970831 @default.
- W2115575892 cites W2109072040 @default.
- W2115575892 cites W2109273258 @default.
- W2115575892 cites W2115482466 @default.
- W2115575892 cites W2117058176 @default.
- W2115575892 cites W2119330162 @default.
- W2115575892 cites W2127338217 @default.
- W2115575892 cites W2132519155 @default.
- W2115575892 cites W2135522980 @default.
- W2115575892 cites W2136868631 @default.
- W2115575892 cites W2136930242 @default.
- W2115575892 cites W2137979644 @default.
- W2115575892 cites W2142120640 @default.
- W2115575892 cites W2145492799 @default.
- W2115575892 cites W2152904049 @default.
- W2115575892 cites W2154112871 @default.
- W2115575892 cites W2158751800 @default.
- W2115575892 cites W2158920269 @default.
- W2115575892 cites W2160696072 @default.
- W2115575892 cites W2160935383 @default.
- W2115575892 cites W2163655775 @default.
- W2115575892 cites W2167025898 @default.
- W2115575892 cites W2169079081 @default.
- W2115575892 cites W2170780799 @default.
- W2115575892 cites W2331108514 @default.
- W2115575892 doi "https://doi.org/10.1002/glia.22522" @default.
- W2115575892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3941074" @default.
- W2115575892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23839956" @default.
- W2115575892 hasPublicationYear "2013" @default.
- W2115575892 type Work @default.
- W2115575892 sameAs 2115575892 @default.
- W2115575892 citedByCount "123" @default.
- W2115575892 countsByYear W21155758922013 @default.
- W2115575892 countsByYear W21155758922014 @default.
- W2115575892 countsByYear W21155758922015 @default.
- W2115575892 countsByYear W21155758922016 @default.
- W2115575892 countsByYear W21155758922017 @default.