Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115576260> ?p ?o ?g. }
- W2115576260 abstract "DNA methylation is a central epigenetic event that regulates cellular differentiation, reprogramming, and pathogenesis. Genomewide DNA demethylation occurs in preimplantation embryos and in embryonic germ cell precursors called primordial germ cells (PGCs). We previously showed that Dppa3, also known as Stella and PGC7, protects the maternal genome from tet methylcytosine dioxygenase 3 (Tet3)-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in zygotes. Here, we demonstrated that retrotransposon genes, such as long interspersed nuclear element-1 (Line-1) and intracisternal A particle (IAP), showed higher 5mC levels in Dppa3-null PGCs. In contrast, oxidative bisulfite sequence analysis revealed that the amounts of 5hmC in Line-1 and IAP were slightly reduced in the Dppa3-deficient PGCs. From our findings, we propose that Dppa3 is involved in the Tet-mediated active demethylation process during reprogramming of PGCs." @default.
- W2115576260 created "2016-06-24" @default.
- W2115576260 creator A5012698520 @default.
- W2115576260 creator A5021979902 @default.
- W2115576260 creator A5059693143 @default.
- W2115576260 creator A5072750877 @default.
- W2115576260 creator A5082270515 @default.
- W2115576260 creator A5089015376 @default.
- W2115576260 creator A5090508355 @default.
- W2115576260 date "2013-05-01" @default.
- W2115576260 modified "2023-09-30" @default.
- W2115576260 title "Effects of Dppa3 on DNA Methylation Dynamics During Primordial Germ Cell Development in Mice1" @default.
- W2115576260 cites W1534122645 @default.
- W2115576260 cites W1574991764 @default.
- W2115576260 cites W1577875429 @default.
- W2115576260 cites W1892165070 @default.
- W2115576260 cites W1967224500 @default.
- W2115576260 cites W1971157495 @default.
- W2115576260 cites W1977388404 @default.
- W2115576260 cites W1979431956 @default.
- W2115576260 cites W1979861092 @default.
- W2115576260 cites W1993762503 @default.
- W2115576260 cites W1993981510 @default.
- W2115576260 cites W1997270596 @default.
- W2115576260 cites W2003608517 @default.
- W2115576260 cites W2004457665 @default.
- W2115576260 cites W2006557744 @default.
- W2115576260 cites W2023844789 @default.
- W2115576260 cites W2026529460 @default.
- W2115576260 cites W2028022342 @default.
- W2115576260 cites W2038722690 @default.
- W2115576260 cites W2044611683 @default.
- W2115576260 cites W2053084007 @default.
- W2115576260 cites W2060446375 @default.
- W2115576260 cites W2067954114 @default.
- W2115576260 cites W2071365780 @default.
- W2115576260 cites W2088708165 @default.
- W2115576260 cites W2089253191 @default.
- W2115576260 cites W2104905992 @default.
- W2115576260 cites W2111694985 @default.
- W2115576260 cites W2121417064 @default.
- W2115576260 cites W2124808094 @default.
- W2115576260 cites W2126235341 @default.
- W2115576260 cites W2131612302 @default.
- W2115576260 cites W2133990340 @default.
- W2115576260 cites W2142745453 @default.
- W2115576260 cites W2147823111 @default.
- W2115576260 cites W2151464048 @default.
- W2115576260 cites W2152589171 @default.
- W2115576260 cites W2162504561 @default.
- W2115576260 cites W2168909179 @default.
- W2115576260 cites W2169066906 @default.
- W2115576260 doi "https://doi.org/10.1095/biolreprod.112.105932" @default.
- W2115576260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23595900" @default.
- W2115576260 hasPublicationYear "2013" @default.
- W2115576260 type Work @default.
- W2115576260 sameAs 2115576260 @default.
- W2115576260 citedByCount "23" @default.
- W2115576260 countsByYear W21155762602014 @default.
- W2115576260 countsByYear W21155762602015 @default.
- W2115576260 countsByYear W21155762602016 @default.
- W2115576260 countsByYear W21155762602017 @default.
- W2115576260 countsByYear W21155762602018 @default.
- W2115576260 countsByYear W21155762602019 @default.
- W2115576260 countsByYear W21155762602020 @default.
- W2115576260 countsByYear W21155762602021 @default.
- W2115576260 countsByYear W21155762602022 @default.
- W2115576260 countsByYear W21155762602023 @default.
- W2115576260 crossrefType "journal-article" @default.
- W2115576260 hasAuthorship W2115576260A5012698520 @default.
- W2115576260 hasAuthorship W2115576260A5021979902 @default.
- W2115576260 hasAuthorship W2115576260A5059693143 @default.
- W2115576260 hasAuthorship W2115576260A5072750877 @default.
- W2115576260 hasAuthorship W2115576260A5082270515 @default.
- W2115576260 hasAuthorship W2115576260A5089015376 @default.
- W2115576260 hasAuthorship W2115576260A5090508355 @default.
- W2115576260 hasBestOaLocation W21155762601 @default.
- W2115576260 hasConcept C104317684 @default.
- W2115576260 hasConcept C150194340 @default.
- W2115576260 hasConcept C153911025 @default.
- W2115576260 hasConcept C16824249 @default.
- W2115576260 hasConcept C190727270 @default.
- W2115576260 hasConcept C2775926025 @default.
- W2115576260 hasConcept C2778901553 @default.
- W2115576260 hasConcept C2779122487 @default.
- W2115576260 hasConcept C33288867 @default.
- W2115576260 hasConcept C41091548 @default.
- W2115576260 hasConcept C54355233 @default.
- W2115576260 hasConcept C552990157 @default.
- W2115576260 hasConcept C77255625 @default.
- W2115576260 hasConcept C86803240 @default.
- W2115576260 hasConcept C95444343 @default.
- W2115576260 hasConceptScore W2115576260C104317684 @default.
- W2115576260 hasConceptScore W2115576260C150194340 @default.
- W2115576260 hasConceptScore W2115576260C153911025 @default.
- W2115576260 hasConceptScore W2115576260C16824249 @default.
- W2115576260 hasConceptScore W2115576260C190727270 @default.
- W2115576260 hasConceptScore W2115576260C2775926025 @default.
- W2115576260 hasConceptScore W2115576260C2778901553 @default.
- W2115576260 hasConceptScore W2115576260C2779122487 @default.