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• W2115580101 abstract "This study was conducted to determine whether overproduction of triglyceride-rich lipoprotein is an obligatory factor for experimental hypertriglyceridemia in nephrotic rats. Nephrosis was induced in male Wistar rats by administration of 150 mg/kg puromycin aminonucleoside. Nephrotic rats had slightly increased triglyceride secretion rate (TGSR) estimated using Triton WR1339 (0.53 * 0.05 vs. 0.45 * 0.04 mg/min, P < 0.05 vs. control rats) and marked hypertriglyceridemia (330.4 * 78.6 mg/dl). Rats made diabetic by 40 mg/kg strep- tozotocin were normotriglyceridemic (66.3 * 12.1 mg/dl) but had suppressed TGSR (0.33 f 0.09 mg/min). Experimental nephrosis was induced in diabetic rats. Their TGSR remained suppressed (0.35 * 0.06 mg/min) but they had marked hyper- triglyceridemia (296.6 * 72.4 mg/dl) suggesting further impair- ment of triglyceride removal from the circulation in diabetic rats caused by nephrosis. Endogenously radiolabeled very low den- sity lipoprotein (VLDL)-triglyceride from donor rats was rein- jected into normal recipient rats. (sH)VLDL from the ex- perimental groups (the rats with nephrosis, diabetes with nephrosis, and diabetes alone) were more slowly cleared by nor- mal rats than VLDL from normal rats. I These results sug- gest that circulating insulin is essential for increased triglyceride secretion in experimental nephrosis and that nephrotic hyper- triglyceridemia can be induced only by a triglyceride removal defect. Therefore, hypersecretion of triglyceride-rich lipoprotein is not an obligatory factor for nephrotic hypertriglyceridemia. - Yoshino, G., T. Hirano, K. Nagata, E. Maeda, Y. Naka, Y. Murata. T. Kazumi, and M. Kasuga. Hypertriglyceridemia in nephrotic rats is due to a clearance defect of plasma triglyceride: overproduction of triglyceride-rich lipoprotein is not an obliga- tory factor. J. Lipid Res. 1993. 34: 875-884." @default.
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• W2115580101 title "Hypertriglyceridemia in nephrotic rats is due to a clearance defect of plasma triglyceride: overproduction of triglyceride-rich lipoprotein is not an obligatory factor" @default.
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• W2115580101 doi "https://doi.org/10.1016/s0022-2275(20)39674-7" @default.
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