FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115596685> ?p ?o ?g. }

• W2115596685 endingPage "113" @default.
• W2115596685 startingPage "104" @default.
• W2115596685 abstract "Primary renal inorganic phosphate (Pi) wasting leads to hypophosphatemia, which is associated with skeletal mineralization defects. In humans, mutations in the gene encoding the type IIc sodium-dependent phosphate transporter lead to hereditary hypophophatemic rickets with hypercalciuria, but whether Pi wasting directly causes the bone disorder is unknown. Here, we generated Npt2c-null mice to define the contribution of Npt2c to Pi homeostasis and to bone abnormalities. Homozygous mutants (Npt2c(-/-)) exhibited hypercalcemia, hypercalciuria, and elevated plasma 1,25-dihydroxyvitamin D(3) levels, but they did not develop hypophosphatemia, hyperphosphaturia, renal calcification, rickets, or osteomalacia. The increased levels of 1,25-dihydroxyvitamin D(3) in Npt2c(-/-) mice compared with age-matched Npt2c(+/+) mice may be the result of reduced catabolism, because we observed significantly reduced expression of renal 25-hydroxyvitamin D-24-hydroxylase mRNA but no change in 1alpha-hydroxylase mRNA levels. Enhanced intestinal absorption of calcium (Ca) contributed to the hypercalcemia and increased urinary Ca excretion. Furthermore, plasma levels of the phosphaturic protein fibroblast growth factor 23 were significantly decreased in Npt2c(-/-) mice. Sodium-dependent Pi co-transport at the renal brush border membrane, however, was not different among Npt2c(+/+), Npt2c(+/-), and Npt2c(-/-) mice. In summary, these data suggest that Npt2c maintains normal Ca metabolism, in part by modulating the vitamin D/fibroblast growth factor 23 axis." @default.
• W2115596685 created "2016-06-24" @default.
• W2115596685 creator A5001620097 @default.
• W2115596685 creator A5003194738 @default.
• W2115596685 creator A5003358015 @default.
• W2115596685 creator A5017265799 @default.
• W2115596685 creator A5037970606 @default.
• W2115596685 creator A5051270255 @default.
• W2115596685 creator A5061044019 @default.
• W2115596685 creator A5063654103 @default.
• W2115596685 creator A5069476050 @default.
• W2115596685 creator A5071477948 @default.
• W2115596685 creator A5072852260 @default.
• W2115596685 creator A5075330695 @default.
• W2115596685 creator A5077823791 @default.
• W2115596685 creator A5091189346 @default.
• W2115596685 date "2009-01-01" @default.
• W2115596685 modified "2023-10-18" @default.
• W2115596685 title "Type IIc Sodium–Dependent Phosphate Transporter Regulates Calcium Metabolism" @default.
• W2115596685 cites W1948548825 @default.
• W2115596685 cites W1967361815 @default.
• W2115596685 cites W1971928855 @default.
• W2115596685 cites W1974493433 @default.
• W2115596685 cites W1982216216 @default.
• W2115596685 cites W1985470651 @default.
• W2115596685 cites W1993922267 @default.
• W2115596685 cites W2018992413 @default.
• W2115596685 cites W2021321428 @default.
• W2115596685 cites W2029511322 @default.
• W2115596685 cites W2037752631 @default.
• W2115596685 cites W2051959338 @default.
• W2115596685 cites W2059629870 @default.
• W2115596685 cites W2070063902 @default.
• W2115596685 cites W2079813075 @default.
• W2115596685 cites W2106107456 @default.
• W2115596685 cites W2116609981 @default.
• W2115596685 cites W2118207122 @default.
• W2115596685 cites W2131064361 @default.
• W2115596685 cites W2145944749 @default.
• W2115596685 cites W2159069028 @default.
• W2115596685 cites W2162972519 @default.
• W2115596685 cites W2168029446 @default.
• W2115596685 cites W2171100097 @default.
• W2115596685 doi "https://doi.org/10.1681/asn.2008020177" @default.
• W2115596685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2615734" @default.
• W2115596685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19056871" @default.
• W2115596685 hasPublicationYear "2009" @default.
• W2115596685 type Work @default.
• W2115596685 sameAs 2115596685 @default.
• W2115596685 citedByCount "116" @default.
• W2115596685 countsByYear W21155966852012 @default.
• W2115596685 countsByYear W21155966852013 @default.
• W2115596685 countsByYear W21155966852014 @default.
• W2115596685 countsByYear W21155966852015 @default.
• W2115596685 countsByYear W21155966852016 @default.
• W2115596685 countsByYear W21155966852017 @default.
• W2115596685 countsByYear W21155966852018 @default.
• W2115596685 countsByYear W21155966852019 @default.
• W2115596685 countsByYear W21155966852020 @default.
• W2115596685 countsByYear W21155966852021 @default.
• W2115596685 countsByYear W21155966852022 @default.
• W2115596685 countsByYear W21155966852023 @default.
• W2115596685 crossrefType "journal-article" @default.
• W2115596685 hasAuthorship W2115596685A5001620097 @default.
• W2115596685 hasAuthorship W2115596685A5003194738 @default.
• W2115596685 hasAuthorship W2115596685A5003358015 @default.
• W2115596685 hasAuthorship W2115596685A5017265799 @default.
• W2115596685 hasAuthorship W2115596685A5037970606 @default.
• W2115596685 hasAuthorship W2115596685A5051270255 @default.
• W2115596685 hasAuthorship W2115596685A5061044019 @default.
• W2115596685 hasAuthorship W2115596685A5063654103 @default.
• W2115596685 hasAuthorship W2115596685A5069476050 @default.
• W2115596685 hasAuthorship W2115596685A5071477948 @default.
• W2115596685 hasAuthorship W2115596685A5072852260 @default.
• W2115596685 hasAuthorship W2115596685A5075330695 @default.
• W2115596685 hasAuthorship W2115596685A5077823791 @default.
• W2115596685 hasAuthorship W2115596685A5091189346 @default.
• W2115596685 hasBestOaLocation W21155966851 @default.
• W2115596685 hasConcept C114276007 @default.
• W2115596685 hasConcept C124490489 @default.
• W2115596685 hasConcept C126322002 @default.
• W2115596685 hasConcept C134018914 @default.
• W2115596685 hasConcept C185592680 @default.
• W2115596685 hasConcept C2776489590 @default.
• W2115596685 hasConcept C2777724520 @default.
• W2115596685 hasConcept C2778049618 @default.
• W2115596685 hasConcept C2778573388 @default.
• W2115596685 hasConcept C2780091579 @default.
• W2115596685 hasConcept C2781145721 @default.
• W2115596685 hasConcept C2781208988 @default.
• W2115596685 hasConcept C2911197707 @default.
• W2115596685 hasConcept C519063684 @default.
• W2115596685 hasConcept C71924100 @default.
• W2115596685 hasConcept C86803240 @default.
• W2115596685 hasConcept C87975464 @default.
• W2115596685 hasConcept C9832595 @default.
• W2115596685 hasConceptScore W2115596685C114276007 @default.
• W2115596685 hasConceptScore W2115596685C124490489 @default.

• next