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- W2115605307 abstract "Background and aims. Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.Methods. Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.Results. The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.Conclusions. We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity." @default.
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- W2115605307 date "2015-09-21" @default.
- W2115605307 modified "2023-10-18" @default.
- W2115605307 title "Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines" @default.
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- W2115605307 doi "https://doi.org/10.15386/cjmed-473" @default.
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