Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115611479> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2115611479 endingPage "190" @default.
- W2115611479 startingPage "184" @default.
- W2115611479 abstract "A method is described for studying platelet function in human whole blood immediately after venepuncture in order to evaluate the antithrombotic potential of new pharmacological agents. In this method, platelet aggregation is quantified by measuring the fall in single platelet count, by using a whole blood platelet counter. We have investigated the platelet aggregation inhibitory effects of the new positive inotropic agents pimobendan and UD CG 212 (reported to be Ca++ sensitisers and phosphodiesterase inhibitors), alone and in combination with dipyridamole. Venous blood was drawn directly into prewarmed (37 degrees C) plastic syringes containing anticoagulants (3.2% trisodium citrate solution) plus a platelet aggregation inhibitor. Spontaneous platelet aggregation (SPA) was studied by roller mixing aliquots of blood in the collecting syringes for 6 min at 37 degrees C. Collagen induced platelet aggregation was studied by incubating aliquots of blood with 1 microgram/ml collagen on a shaking water bath for 3 min. In the absence of an inhibitor, there was a 50% fall in single platelet count due to SPA and a 65% fall was induced by collagen. Both SPA and collagen induced aggregation responses were inhibited by pimobendan (0.5-10 microM) and UD CG 212 (0.5-10 microM), in a dose dependent manner. A combination of 10 microM dipyridamole with 2 microM pimobendan or UD CG 212 was markedly a more effective inhibitor of platelet aggregation than a high dose of either inhibitor alone. It is suggested that the present method is simple and rapid, with minimal sample processing, and therefore the results may be protected from serious artifacts.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2115611479 created "2016-06-24" @default.
- W2115611479 creator A5018841613 @default.
- W2115611479 creator A5033515344 @default.
- W2115611479 creator A5069794181 @default.
- W2115611479 creator A5088521526 @default.
- W2115611479 date "1989-03-01" @default.
- W2115611479 modified "2023-10-03" @default.
- W2115611479 title "Platelet aggregation inhibitory effects of the new positive inotropic agents pimobendan and UD CG 212 in whole blood" @default.
- W2115611479 doi "https://doi.org/10.1093/cvr/23.3.184" @default.
- W2115611479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2590903" @default.
- W2115611479 hasPublicationYear "1989" @default.
- W2115611479 type Work @default.
- W2115611479 sameAs 2115611479 @default.
- W2115611479 citedByCount "10" @default.
- W2115611479 countsByYear W21156114792012 @default.
- W2115611479 countsByYear W21156114792013 @default.
- W2115611479 countsByYear W21156114792015 @default.
- W2115611479 countsByYear W21156114792017 @default.
- W2115611479 countsByYear W21156114792023 @default.
- W2115611479 crossrefType "journal-article" @default.
- W2115611479 hasAuthorship W2115611479A5018841613 @default.
- W2115611479 hasAuthorship W2115611479A5033515344 @default.
- W2115611479 hasAuthorship W2115611479A5069794181 @default.
- W2115611479 hasAuthorship W2115611479A5088521526 @default.
- W2115611479 hasConcept C126322002 @default.
- W2115611479 hasConcept C1621761 @default.
- W2115611479 hasConcept C185592680 @default.
- W2115611479 hasConcept C2776766087 @default.
- W2115611479 hasConcept C2776890861 @default.
- W2115611479 hasConcept C2777015399 @default.
- W2115611479 hasConcept C2777738910 @default.
- W2115611479 hasConcept C55493867 @default.
- W2115611479 hasConcept C71924100 @default.
- W2115611479 hasConcept C89560881 @default.
- W2115611479 hasConcept C98274493 @default.
- W2115611479 hasConceptScore W2115611479C126322002 @default.
- W2115611479 hasConceptScore W2115611479C1621761 @default.
- W2115611479 hasConceptScore W2115611479C185592680 @default.
- W2115611479 hasConceptScore W2115611479C2776766087 @default.
- W2115611479 hasConceptScore W2115611479C2776890861 @default.
- W2115611479 hasConceptScore W2115611479C2777015399 @default.
- W2115611479 hasConceptScore W2115611479C2777738910 @default.
- W2115611479 hasConceptScore W2115611479C55493867 @default.
- W2115611479 hasConceptScore W2115611479C71924100 @default.
- W2115611479 hasConceptScore W2115611479C89560881 @default.
- W2115611479 hasConceptScore W2115611479C98274493 @default.
- W2115611479 hasIssue "3" @default.
- W2115611479 hasLocation W21156114791 @default.
- W2115611479 hasLocation W21156114792 @default.
- W2115611479 hasOpenAccess W2115611479 @default.
- W2115611479 hasPrimaryLocation W21156114791 @default.
- W2115611479 hasRelatedWork W104407421 @default.
- W2115611479 hasRelatedWork W146983984 @default.
- W2115611479 hasRelatedWork W1559198498 @default.
- W2115611479 hasRelatedWork W1978781060 @default.
- W2115611479 hasRelatedWork W1982615572 @default.
- W2115611479 hasRelatedWork W2078061467 @default.
- W2115611479 hasRelatedWork W2416504887 @default.
- W2115611479 hasRelatedWork W2419531318 @default.
- W2115611479 hasRelatedWork W2462760285 @default.
- W2115611479 hasRelatedWork W4246598251 @default.
- W2115611479 hasVolume "23" @default.
- W2115611479 isParatext "false" @default.
- W2115611479 isRetracted "false" @default.
- W2115611479 magId "2115611479" @default.
- W2115611479 workType "article" @default.