FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115617775> ?p ?o ?g. }

• W2115617775 endingPage "456" @default.
• W2115617775 startingPage "449" @default.
• W2115617775 abstract "The bone morphogenetic protein/Signaling mothers against decapentaplegic (BMP/Smad) and the WNT signaling pathways regulate the commitment of mesenchymal cells to the osteoblastic lineage. Nemo-like kinase (Nlk) is an evolutionary conserved kinase that suppresses Smad transactivation and WNT canonical signaling. However, it is not clear whether these effects of Nlk have any consequence on the differentiation of mammalian cells. To study the function of Nlk during the commitment of ST-2 bone marrow stromal cells to the osteoblastic fate, Nlk was downregulated by RNA interference (RNAi), following transfection of a specific small interfering (si)RNA. Nlk downregulation increased alkaline phosphatase and osteocalcin expression and sensitized ST-2 cells to the effects of BMP2 and WNT3 on alkaline phosphatase mRNA expression and activity. Accordingly, Nlk downregulation enhanced the effect of BMP2 on the transactivation of the BMP/Smad reporter construct 12xSBE-Oc-pGL3, and on the levels of phosphorylated Smad1/5/8, whereas it did not affect the transactivation of the transforming growth factor-β/Smad reporter pSBE-Luc. Nlk downregulation sensitized ST-2 cells to the effects of WNT3 on the transactivation of the WNT/T-cell factor (Tcf) reporter construct 16xTCF-Luc, whereas it did not affect cytosolic β-catenin levels. To understand the function of Nlk in cells committed to the osteoblastic lineage, Nlk was suppressed by RNAi in primary calvarial osteoblasts. Downregulation of Nlk increased alkaline phosphatase and osteocalcin transcripts and sensitized osteoblasts to the effects of BMP2 on alkaline phosphatase activity and Smad1/5/8 transactivation and phosphorylation. In conclusion, Nlk suppresses osteoblastogenesis by opposing BMP/Smad and WNT canonical signaling." @default.
• W2115617775 created "2016-06-24" @default.
• W2115617775 creator A5004430702 @default.
• W2115617775 creator A5029972696 @default.
• W2115617775 date "2012-01-05" @default.
• W2115617775 modified "2023-10-07" @default.
• W2115617775 title "Nemo‐like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling" @default.
• W2115617775 cites W1609684706 @default.
• W2115617775 cites W1611419331 @default.
• W2115617775 cites W1780096456 @default.
• W2115617775 cites W1902879109 @default.
• W2115617775 cites W1973163775 @default.
• W2115617775 cites W1981040688 @default.
• W2115617775 cites W1981791036 @default.
• W2115617775 cites W1986426572 @default.
• W2115617775 cites W1989610585 @default.
• W2115617775 cites W1994798295 @default.
• W2115617775 cites W1997180986 @default.
• W2115617775 cites W1997989974 @default.
• W2115617775 cites W2007044718 @default.
• W2115617775 cites W2007124097 @default.
• W2115617775 cites W2011767107 @default.
• W2115617775 cites W2021323848 @default.
• W2115617775 cites W2040475603 @default.
• W2115617775 cites W2051385471 @default.
• W2115617775 cites W2056806024 @default.
• W2115617775 cites W2058056564 @default.
• W2115617775 cites W2064000380 @default.
• W2115617775 cites W2065797262 @default.
• W2115617775 cites W2071035473 @default.
• W2115617775 cites W2073269248 @default.
• W2115617775 cites W2077789375 @default.
• W2115617775 cites W2079562282 @default.
• W2115617775 cites W2100808809 @default.
• W2115617775 cites W2107003456 @default.
• W2115617775 cites W2112349562 @default.
• W2115617775 cites W2113359377 @default.
• W2115617775 cites W2122803804 @default.
• W2115617775 cites W2124385965 @default.
• W2115617775 cites W2148676064 @default.
• W2115617775 cites W2155222830 @default.
• W2115617775 cites W2157463520 @default.
• W2115617775 cites W2158021558 @default.
• W2115617775 cites W2161307536 @default.
• W2115617775 cites W4235438234 @default.
• W2115617775 cites W4296588288 @default.
• W2115617775 doi "https://doi.org/10.1002/jcb.23365" @default.
• W2115617775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253257" @default.
• W2115617775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21928348" @default.
• W2115617775 hasPublicationYear "2012" @default.
• W2115617775 type Work @default.
• W2115617775 sameAs 2115617775 @default.
• W2115617775 citedByCount "15" @default.
• W2115617775 countsByYear W21156177752013 @default.
• W2115617775 countsByYear W21156177752014 @default.
• W2115617775 countsByYear W21156177752015 @default.
• W2115617775 countsByYear W21156177752016 @default.
• W2115617775 countsByYear W21156177752017 @default.
• W2115617775 countsByYear W21156177752018 @default.
• W2115617775 crossrefType "journal-article" @default.
• W2115617775 hasAuthorship W2115617775A5004430702 @default.
• W2115617775 hasAuthorship W2115617775A5029972696 @default.
• W2115617775 hasBestOaLocation W21156177752 @default.
• W2115617775 hasConcept C104317684 @default.
• W2115617775 hasConcept C127561419 @default.
• W2115617775 hasConcept C1292079 @default.
• W2115617775 hasConcept C131075544 @default.
• W2115617775 hasConcept C137620995 @default.
• W2115617775 hasConcept C160160445 @default.
• W2115617775 hasConcept C181199279 @default.
• W2115617775 hasConcept C185592680 @default.
• W2115617775 hasConcept C202751555 @default.
• W2115617775 hasConcept C2781080636 @default.
• W2115617775 hasConcept C30352789 @default.
• W2115617775 hasConcept C502942594 @default.
• W2115617775 hasConcept C55493867 @default.
• W2115617775 hasConcept C62478195 @default.
• W2115617775 hasConcept C86339819 @default.
• W2115617775 hasConcept C86803240 @default.
• W2115617775 hasConcept C95444343 @default.
• W2115617775 hasConceptScore W2115617775C104317684 @default.
• W2115617775 hasConceptScore W2115617775C127561419 @default.
• W2115617775 hasConceptScore W2115617775C1292079 @default.
• W2115617775 hasConceptScore W2115617775C131075544 @default.
• W2115617775 hasConceptScore W2115617775C137620995 @default.
• W2115617775 hasConceptScore W2115617775C160160445 @default.
• W2115617775 hasConceptScore W2115617775C181199279 @default.
• W2115617775 hasConceptScore W2115617775C185592680 @default.
• W2115617775 hasConceptScore W2115617775C202751555 @default.
• W2115617775 hasConceptScore W2115617775C2781080636 @default.
• W2115617775 hasConceptScore W2115617775C30352789 @default.
• W2115617775 hasConceptScore W2115617775C502942594 @default.
• W2115617775 hasConceptScore W2115617775C55493867 @default.
• W2115617775 hasConceptScore W2115617775C62478195 @default.
• W2115617775 hasConceptScore W2115617775C86339819 @default.
• W2115617775 hasConceptScore W2115617775C86803240 @default.
• W2115617775 hasConceptScore W2115617775C95444343 @default.
• W2115617775 hasIssue "2" @default.

• next