Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115620208> ?p ?o ?g. }
- W2115620208 endingPage "1038" @default.
- W2115620208 startingPage "1025" @default.
- W2115620208 abstract "Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize misfolded protein-induced cytotoxicity. However, the molecular mechanism by which misfolded proteins are recruited to aggresomes remains unclear. Mutations in the E3 ligase parkin cause autosomal recessive Parkinson's disease that is devoid of Lewy bodies, which are similar to aggresomes. Here, we report that parkin cooperates with heterodimeric E2 enzyme UbcH13/Uev1a to mediate K63-linked polyubiquitination of misfolded DJ-1. K63-linked polyubiquitination of misfolded DJ-1 serves as a signal for interaction with histone deacetylase 6, an adaptor protein that binds the dynein–dynactin complex. Through this interaction, misfolded DJ-1 is linked to the dynein motor and transported to aggresomes. Furthermore, fibroblasts lacking parkin display deficits in targeting misfolded DJ-1 to aggresomes. Our findings reveal a signaling role for K63-linked polyubiquitination in dynein-mediated transport, identify parkin as a key regulator in the recruitment of misfolded DJ-1 to aggresomes, and have important implications regarding the biogenesis of Lewy bodies." @default.
- W2115620208 created "2016-06-24" @default.
- W2115620208 creator A5000323703 @default.
- W2115620208 creator A5014215141 @default.
- W2115620208 creator A5027222229 @default.
- W2115620208 creator A5040554820 @default.
- W2115620208 creator A5042484728 @default.
- W2115620208 creator A5055765486 @default.
- W2115620208 creator A5091732817 @default.
- W2115620208 date "2007-09-10" @default.
- W2115620208 modified "2023-10-16" @default.
- W2115620208 title "Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6" @default.
- W2115620208 cites W1550876205 @default.
- W2115620208 cites W1599366903 @default.
- W2115620208 cites W1600472471 @default.
- W2115620208 cites W1780544763 @default.
- W2115620208 cites W1877873625 @default.
- W2115620208 cites W1933870215 @default.
- W2115620208 cites W1966773864 @default.
- W2115620208 cites W1967603366 @default.
- W2115620208 cites W1972049807 @default.
- W2115620208 cites W1981500782 @default.
- W2115620208 cites W1982167929 @default.
- W2115620208 cites W1983892290 @default.
- W2115620208 cites W1986188355 @default.
- W2115620208 cites W1988146888 @default.
- W2115620208 cites W1988457275 @default.
- W2115620208 cites W1989498124 @default.
- W2115620208 cites W1994452430 @default.
- W2115620208 cites W1997369314 @default.
- W2115620208 cites W2004821943 @default.
- W2115620208 cites W2007945544 @default.
- W2115620208 cites W2009125409 @default.
- W2115620208 cites W2011339216 @default.
- W2115620208 cites W2012176044 @default.
- W2115620208 cites W2012844038 @default.
- W2115620208 cites W2014301084 @default.
- W2115620208 cites W2021242983 @default.
- W2115620208 cites W2024891592 @default.
- W2115620208 cites W2028267102 @default.
- W2115620208 cites W2029287748 @default.
- W2115620208 cites W2035531816 @default.
- W2115620208 cites W2037454778 @default.
- W2115620208 cites W2043594547 @default.
- W2115620208 cites W2047455709 @default.
- W2115620208 cites W2062454540 @default.
- W2115620208 cites W2068213179 @default.
- W2115620208 cites W2069403245 @default.
- W2115620208 cites W2069479107 @default.
- W2115620208 cites W2076344205 @default.
- W2115620208 cites W2079046408 @default.
- W2115620208 cites W2079103662 @default.
- W2115620208 cites W2080853928 @default.
- W2115620208 cites W2081737819 @default.
- W2115620208 cites W2086561195 @default.
- W2115620208 cites W2086677084 @default.
- W2115620208 cites W2088962120 @default.
- W2115620208 cites W2090926709 @default.
- W2115620208 cites W2091767225 @default.
- W2115620208 cites W2097965815 @default.
- W2115620208 cites W2103551853 @default.
- W2115620208 cites W2104382960 @default.
- W2115620208 cites W2105249930 @default.
- W2115620208 cites W2105631970 @default.
- W2115620208 cites W2107977469 @default.
- W2115620208 cites W2110780830 @default.
- W2115620208 cites W2111426001 @default.
- W2115620208 cites W2113635620 @default.
- W2115620208 cites W2114939802 @default.
- W2115620208 cites W2117018286 @default.
- W2115620208 cites W2120706471 @default.
- W2115620208 cites W2123550556 @default.
- W2115620208 cites W2129698492 @default.
- W2115620208 cites W2130792966 @default.
- W2115620208 cites W2133407217 @default.
- W2115620208 cites W2133550059 @default.
- W2115620208 cites W2139947061 @default.
- W2115620208 cites W2144713781 @default.
- W2115620208 cites W2146620343 @default.
- W2115620208 cites W2149761960 @default.
- W2115620208 cites W2150157946 @default.
- W2115620208 cites W2152330309 @default.
- W2115620208 cites W2154506764 @default.
- W2115620208 cites W2159081975 @default.
- W2115620208 cites W2164065816 @default.
- W2115620208 cites W2166427186 @default.
- W2115620208 cites W2168637323 @default.
- W2115620208 cites W2317804643 @default.
- W2115620208 cites W2473580629 @default.
- W2115620208 doi "https://doi.org/10.1083/jcb.200611128" @default.
- W2115620208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064625" @default.
- W2115620208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17846173" @default.
- W2115620208 hasPublicationYear "2007" @default.
- W2115620208 type Work @default.
- W2115620208 sameAs 2115620208 @default.
- W2115620208 citedByCount "315" @default.
- W2115620208 countsByYear W21156202082012 @default.
- W2115620208 countsByYear W21156202082013 @default.