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• W2115629204 abstract "The effects of substituting gluconate for extracellular Cl, and of treatment with various ion transport blockers, on cytosol pH (pH i ) and secretion by the acetylcholine stimulated rat mandibular gland were studied in vitro. Gluconate replacement increased pH i from 7.12 ± 0.02 to 7.27 ± 0.04, caused secretory rate to fall by 75%, and increased salivary HC03 from 14 ± 0.9 mmollL to 67 ± 1.5 mmoll L. Furosemide (I mmol/L), which blocks Na-K-2Cl symports and Cl-HCO 3 antiports, had effects similar to those of gluconate replacement, except that secretion was reduced only by 59%. Bumetanide (1 mmoll L), which blocks only Na-K-2Cl symports, caused a 67% reduction in secretion rate, but it had little effect on pH i and caused only a small rise in salivary HCO 3 concentration. SITS (1 mmol/L), which blocks Cl-HCO 3 antiports, increased pH i to 7.26 ± 0.03 and induced a small rise in the secretory rate. Methazolamide and acetazolamide (1 mmol/L), both of which inhibit carbonic anhydrase and may also block anion channels, increased pH i to 7.43 ± 0.02 and 7.20 ± 0.03, respectively, but had no effect on secretory rate, and reduced salivary HC03 slightly. Ba (3 mmol/L), tetraethylammonium (10 mmoll L), and decamethonium (5 mmol/L) all caused marked but reversible reductions in secretory rate, consistent with the known actions of these agents on K channels. Ba, however, also appeared to act as a Ca antagonist, an action that it seemed to share with Mn ions (5 mmoll L). The results are interpreted in terms of a secretion model based on the presence, in the baso-lateral plasma membranes of the secretory cells, not only of a Na-K-2Cl symport, but also of Na-H and Cl-HC03 antiports, contributing, respectively, to secretion in the proportions 8:5:3." @default.
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• W2115629204 date "1987-02-01" @default.
• W2115629204 modified "2023-10-18" @default.
• W2115629204 title "Effects of Ion Transport Inhibition on Rat Mandibular Gland Secretion" @default.
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• W2115629204 doi "https://doi.org/10.1177/00220345870660022401" @default.
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