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- W2115638672 abstract "Dihydrobenzoxazinones and dihydroquinazolinones are the core units present in many anti-HIV agents, such as Efavirenz, DPC 961, DPC 963, and DPC 083. All these molecules contain a trifluoromethyl moiety at the quaternary stereogenic carbon center with S configuration. The enantioselective addition of carbon nucleophiles to ketones or cyclic ketimines could serve as a key step to access these molecules. This tutorial review provides an overview of significant advances in the synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents and relative analogues, with an emphasis on asymmetric addition reactions for the establishment of the CF3-containing quaternary carbon centers." @default.
- W2115638672 created "2016-06-24" @default.
- W2115638672 creator A5024804683 @default.
- W2115638672 creator A5040829256 @default.
- W2115638672 date "2015-01-01" @default.
- W2115638672 modified "2023-10-18" @default.
- W2115638672 title "Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents" @default.
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- W2115638672 doi "https://doi.org/10.1039/c5cs00342c" @default.
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