FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115645562> ?p ?o ?g. }

• W2115645562 endingPage "3239" @default.
• W2115645562 startingPage "3232" @default.
• W2115645562 abstract "Leishmaniasis, caused by infection with the protozoan parasite Leishmania, affects millions of individuals worldwide, causing serious morbidity and mortality. This study directly determined the frequency of cells producing key immunoregulatory cytokines in response to the recombinant antigen Leishmania homolog of receptors for activated kinase C (LACK) and soluble leishmania antigen (SLA), and it determined relative contributions of these antigens to the overall cytokine profile in individuals infected for the first time with Leishmania braziliensis. All individuals presented with the cutaneous clinical form of leishmaniasis and were analyzed for proliferative responses to LACK antigen and SLA, frequency of lymphocyte subpopulations (analyzed ex vivo), and antigen-induced (LACK and SLA) cytokine production at the single-cell level (determined by flow cytometry). The following were determined. (i) The Th1-type response previously seen in patients with cutaneous leishmaniasis is due to gamma interferon (IFN-gamma) production by several different sources, listed in order of contribution: CD4(+) T lymphocytes, CD4(-), CD8(-) lymphocytes, and CD8(+) T lymphocytes. (ii) SLA induced a higher frequency of lymphocytes producing IFN-gamma and tumor necrosis factor alpha (TNF-alpha) than did LACK. (iii) LACK induced an activation of monocyte populations as reflected by an increased percentage of CD14-positive cells. (iv) Neither SLA nor LACK induced detectable frequencies of cells producing interleukin-4 (IL-4) or IL-5. These data demonstrated a multifaceted immune response to SLA in human leishmaniasis involving Th1 CD4(+) T lymphocytes (IFN-gamma(+) and IL-10(-)/IL-4(-)), Tc1 CD8(+) T cells (IFN-gamma(+), and IL-10(-)/IL-4(-)), and a high frequency of TNF-alpha-producing lymphocytes. Moreover, it was determined that the recombinant antigen LACK acts as a weak inducer of Th1-type lymphocyte responses compared to SLA." @default.
• W2115645562 created "2016-06-24" @default.
• W2115645562 creator A5005281876 @default.
• W2115645562 creator A5017399345 @default.
• W2115645562 creator A5019661287 @default.
• W2115645562 creator A5026281432 @default.
• W2115645562 creator A5053471036 @default.
• W2115645562 creator A5057728580 @default.
• W2115645562 creator A5061188770 @default.
• W2115645562 creator A5066993086 @default.
• W2115645562 creator A5068420259 @default.
• W2115645562 creator A5071978277 @default.
• W2115645562 creator A5072253499 @default.
• W2115645562 date "2001-05-01" @default.
• W2115645562 modified "2023-09-26" @default.
• W2115645562 title "Flow Cytometric Determination of Cellular Sources and Frequencies of Key Cytokine-Producing Lymphocytes Directed against Recombinant LACK and Soluble Leishmania Antigen in Human Cutaneous Leishmaniasis" @default.
• W2115645562 cites W1499120760 @default.
• W2115645562 cites W1552315819 @default.
• W2115645562 cites W1558591463 @default.
• W2115645562 cites W1946880381 @default.
• W2115645562 cites W1973700190 @default.
• W2115645562 cites W2010155234 @default.
• W2115645562 cites W2027481108 @default.
• W2115645562 cites W2043850455 @default.
• W2115645562 cites W2063028941 @default.
• W2115645562 cites W2105431760 @default.
• W2115645562 cites W2117451755 @default.
• W2115645562 cites W2140627356 @default.
• W2115645562 cites W2147627497 @default.
• W2115645562 cites W2413936724 @default.
• W2115645562 cites W2415653577 @default.
• W2115645562 cites W2766652629 @default.
• W2115645562 cites W4238258575 @default.
• W2115645562 cites W4300804869 @default.
• W2115645562 cites W4313377043 @default.
• W2115645562 cites W958023699 @default.
• W2115645562 doi "https://doi.org/10.1128/iai.69.5.3232-3239.2001" @default.
• W2115645562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/98281" @default.
• W2115645562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11292745" @default.
• W2115645562 hasPublicationYear "2001" @default.
• W2115645562 type Work @default.
• W2115645562 sameAs 2115645562 @default.
• W2115645562 citedByCount "112" @default.
• W2115645562 countsByYear W21156455622012 @default.
• W2115645562 countsByYear W21156455622013 @default.
• W2115645562 countsByYear W21156455622014 @default.
• W2115645562 countsByYear W21156455622015 @default.
• W2115645562 countsByYear W21156455622016 @default.
• W2115645562 countsByYear W21156455622017 @default.
• W2115645562 countsByYear W21156455622018 @default.
• W2115645562 countsByYear W21156455622019 @default.
• W2115645562 countsByYear W21156455622020 @default.
• W2115645562 countsByYear W21156455622021 @default.
• W2115645562 countsByYear W21156455622022 @default.
• W2115645562 countsByYear W21156455622023 @default.
• W2115645562 crossrefType "journal-article" @default.
• W2115645562 hasAuthorship W2115645562A5005281876 @default.
• W2115645562 hasAuthorship W2115645562A5017399345 @default.
• W2115645562 hasAuthorship W2115645562A5019661287 @default.
• W2115645562 hasAuthorship W2115645562A5026281432 @default.
• W2115645562 hasAuthorship W2115645562A5053471036 @default.
• W2115645562 hasAuthorship W2115645562A5057728580 @default.
• W2115645562 hasAuthorship W2115645562A5061188770 @default.
• W2115645562 hasAuthorship W2115645562A5066993086 @default.
• W2115645562 hasAuthorship W2115645562A5068420259 @default.
• W2115645562 hasAuthorship W2115645562A5071978277 @default.
• W2115645562 hasAuthorship W2115645562A5072253499 @default.
• W2115645562 hasBestOaLocation W21156455622 @default.
• W2115645562 hasConcept C136764020 @default.
• W2115645562 hasConcept C147483822 @default.
• W2115645562 hasConcept C154317977 @default.
• W2115645562 hasConcept C167672396 @default.
• W2115645562 hasConcept C17991360 @default.
• W2115645562 hasConcept C202751555 @default.
• W2115645562 hasConcept C203014093 @default.
• W2115645562 hasConcept C2776555147 @default.
• W2115645562 hasConcept C2777371288 @default.
• W2115645562 hasConcept C2778690821 @default.
• W2115645562 hasConcept C2778702967 @default.
• W2115645562 hasConcept C2780599195 @default.
• W2115645562 hasConcept C2780841837 @default.
• W2115645562 hasConcept C2781092759 @default.
• W2115645562 hasConcept C2992881475 @default.
• W2115645562 hasConcept C41008148 @default.
• W2115645562 hasConcept C55493867 @default.
• W2115645562 hasConcept C71928629 @default.
• W2115645562 hasConcept C86803240 @default.
• W2115645562 hasConcept C8891405 @default.
• W2115645562 hasConceptScore W2115645562C136764020 @default.
• W2115645562 hasConceptScore W2115645562C147483822 @default.
• W2115645562 hasConceptScore W2115645562C154317977 @default.
• W2115645562 hasConceptScore W2115645562C167672396 @default.
• W2115645562 hasConceptScore W2115645562C17991360 @default.
• W2115645562 hasConceptScore W2115645562C202751555 @default.
• W2115645562 hasConceptScore W2115645562C203014093 @default.
• W2115645562 hasConceptScore W2115645562C2776555147 @default.
• W2115645562 hasConceptScore W2115645562C2777371288 @default.
• W2115645562 hasConceptScore W2115645562C2778690821 @default.

• next