Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115655589> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2115655589 endingPage "189" @default.
- W2115655589 startingPage "179" @default.
- W2115655589 abstract "Expression of neoantigens during denaturation of IgG by oxygen radicals or proteolysis was assumed to be a possible mechanism for stimulation of rheumatoid factor (RF) formation and/or granulocyte dependent inflammative joint destruction. The so-called human leukocyte elastase (HLE) regularly released by stimulated neutrophils f.e. into the RA synovial fluid is known to split IgG in vitro into papain like fragments and low molecular weight peptides. The n-terminal site of the HLE related Fc is bearing a neoantigenic group which is located near the hinge region but not expressed by the native IgG. The neoantigen itself is represented by the low molecular weight peptides produced by prolonged HLE-IgG proteolysis.Detection of HLE generated Fc in synovial fluids was performed by radioimmunoassay specific for the neoantigen. Patients were divided into the three groups; I RA (n = 23), II inflammative joint effusions except RA (n = 23), III osteoarthritis and trauma (n = 19). The biological effect of the neoantigen on to granulocyte oxidative metabolism was tested by Cytochrome C reduction and chemiluminescence.Neoantigen bearing Fc could be detected in 15 of 23 cases of group I, in group II in 11 of 23 cases and only in 7 of 19 cases in group III. The median concentrations were 0.62 μg in group I and zero in II and III.The HLE derived Fc were able to inhibit the oxidative metabolism of activated granulocytes in vitro. The O2- production of stimulated granulocytes was depressed dose dependent by the neoantigen.The neoantigenic group itself does not react with RF as proved by nephelometric titration of HLE derived Fc, neoantigenic peptide and native IgG against a RF standard." @default.
- W2115655589 created "2016-06-24" @default.
- W2115655589 creator A5019698934 @default.
- W2115655589 creator A5026482900 @default.
- W2115655589 creator A5026866835 @default.
- W2115655589 creator A5052456391 @default.
- W2115655589 creator A5070961961 @default.
- W2115655589 date "1988-01-01" @default.
- W2115655589 modified "2023-09-25" @default.
- W2115655589 title "Neoantigenic Group on Fc Fragments in Rheumatoid Arthritis Synovial Fluids" @default.
- W2115655589 cites W1983470937 @default.
- W2115655589 cites W2029084181 @default.
- W2115655589 cites W2044815433 @default.
- W2115655589 cites W2046576640 @default.
- W2115655589 cites W2069718808 @default.
- W2115655589 cites W2091876434 @default.
- W2115655589 cites W2107873069 @default.
- W2115655589 cites W2332900492 @default.
- W2115655589 cites W2401077755 @default.
- W2115655589 cites W258376682 @default.
- W2115655589 cites W302938682 @default.
- W2115655589 doi "https://doi.org/10.3109/03009748809096760" @default.
- W2115655589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2467351" @default.
- W2115655589 hasPublicationYear "1988" @default.
- W2115655589 type Work @default.
- W2115655589 sameAs 2115655589 @default.
- W2115655589 citedByCount "8" @default.
- W2115655589 countsByYear W21156555892017 @default.
- W2115655589 crossrefType "journal-article" @default.
- W2115655589 hasAuthorship W2115655589A5019698934 @default.
- W2115655589 hasAuthorship W2115655589A5026482900 @default.
- W2115655589 hasAuthorship W2115655589A5026866835 @default.
- W2115655589 hasAuthorship W2115655589A5052456391 @default.
- W2115655589 hasAuthorship W2115655589A5070961961 @default.
- W2115655589 hasConcept C126322002 @default.
- W2115655589 hasConcept C134018914 @default.
- W2115655589 hasConcept C142724271 @default.
- W2115655589 hasConcept C153911025 @default.
- W2115655589 hasConcept C176685330 @default.
- W2115655589 hasConcept C181199279 @default.
- W2115655589 hasConcept C185592680 @default.
- W2115655589 hasConcept C202751555 @default.
- W2115655589 hasConcept C203014093 @default.
- W2115655589 hasConcept C204787440 @default.
- W2115655589 hasConcept C2776164576 @default.
- W2115655589 hasConcept C2776232647 @default.
- W2115655589 hasConcept C2776268809 @default.
- W2115655589 hasConcept C2777575956 @default.
- W2115655589 hasConcept C2777983669 @default.
- W2115655589 hasConcept C2780678043 @default.
- W2115655589 hasConcept C2781044401 @default.
- W2115655589 hasConcept C2781307694 @default.
- W2115655589 hasConcept C55493867 @default.
- W2115655589 hasConcept C71924100 @default.
- W2115655589 hasConcept C86803240 @default.
- W2115655589 hasConceptScore W2115655589C126322002 @default.
- W2115655589 hasConceptScore W2115655589C134018914 @default.
- W2115655589 hasConceptScore W2115655589C142724271 @default.
- W2115655589 hasConceptScore W2115655589C153911025 @default.
- W2115655589 hasConceptScore W2115655589C176685330 @default.
- W2115655589 hasConceptScore W2115655589C181199279 @default.
- W2115655589 hasConceptScore W2115655589C185592680 @default.
- W2115655589 hasConceptScore W2115655589C202751555 @default.
- W2115655589 hasConceptScore W2115655589C203014093 @default.
- W2115655589 hasConceptScore W2115655589C204787440 @default.
- W2115655589 hasConceptScore W2115655589C2776164576 @default.
- W2115655589 hasConceptScore W2115655589C2776232647 @default.
- W2115655589 hasConceptScore W2115655589C2776268809 @default.
- W2115655589 hasConceptScore W2115655589C2777575956 @default.
- W2115655589 hasConceptScore W2115655589C2777983669 @default.
- W2115655589 hasConceptScore W2115655589C2780678043 @default.
- W2115655589 hasConceptScore W2115655589C2781044401 @default.
- W2115655589 hasConceptScore W2115655589C2781307694 @default.
- W2115655589 hasConceptScore W2115655589C55493867 @default.
- W2115655589 hasConceptScore W2115655589C71924100 @default.
- W2115655589 hasConceptScore W2115655589C86803240 @default.
- W2115655589 hasIssue "sup75" @default.
- W2115655589 hasLocation W21156555891 @default.
- W2115655589 hasLocation W21156555892 @default.
- W2115655589 hasOpenAccess W2115655589 @default.
- W2115655589 hasPrimaryLocation W21156555891 @default.
- W2115655589 hasRelatedWork W1487307469 @default.
- W2115655589 hasRelatedWork W2043105234 @default.
- W2115655589 hasRelatedWork W2111012346 @default.
- W2115655589 hasRelatedWork W2115655589 @default.
- W2115655589 hasRelatedWork W2207985802 @default.
- W2115655589 hasRelatedWork W2413413704 @default.
- W2115655589 hasRelatedWork W2417962227 @default.
- W2115655589 hasRelatedWork W2418490029 @default.
- W2115655589 hasRelatedWork W2466470299 @default.
- W2115655589 hasRelatedWork W331123206 @default.
- W2115655589 hasVolume "17" @default.
- W2115655589 isParatext "false" @default.
- W2115655589 isRetracted "false" @default.
- W2115655589 magId "2115655589" @default.
- W2115655589 workType "article" @default.