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• W2115663485 abstract "ABSTRACT A strain of Mycobacterium bovis BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG MCP-3 ) was developed. Mice vaccinated with BCG MCP-3 displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated with BCG alone. The level of protection afforded by BCG MCP-3 was equivalent to that with control BCG; however, immunodeficient mice infected with BCG MCP-3 survived significantly longer than mice infected with the control BCG strain. Therefore, BCG MCP-3 may be a safer alternative than conventional BCG for vaccination of immunocompromised individuals." @default.
• W2115663485 created "2016-06-24" @default.
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• W2115663485 date "2007-01-01" @default.
• W2115663485 modified "2023-10-16" @default.
• W2115663485 title "Secretion of Functional Monocyte Chemotactic Protein 3 by Recombinant<i>Mycobacterium bovis</i>BCG Attenuates Vaccine Virulence and Maintains Protective Efficacy against<i>M. tuberculosis</i>Infection" @default.
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• W2115663485 doi "https://doi.org/10.1128/iai.00897-06" @default.
• W2115663485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1828426" @default.
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