FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115664315> ?p ?o ?g. }

• W2115664315 endingPage "6985" @default.
• W2115664315 startingPage "6978" @default.
• W2115664315 abstract "Abstract The Kaposi’s sarcoma-associated herpesvirus-encoded ubiquitin E3 ligase K3 ubiquitinates cell-surface MHC class I molecules (MHC I), causing the internalization and degradation of MHC I via the endolysosomal pathway. K3 recruits the cellular E2 ubiquitin-conjugating enzyme Ubc13 to generate lysine-63–linked polyubiquitin chains on MHC I, leading to the clathrin-mediated endocytosis and lysosomal degradation of MHC I. In this study, we identify a ubiquitin isoleucine-44-alanine mutant (I44A) that inhibits K3-mediated downregulation of MHC I by preventing MHC I polyubiqitination. This E3-specific inhibition by I44A prevents dissociation of the MHC I–K3–Ubc13–ubiquitin complex, allows the in vivo visualization of a transient substrate–E3–E2–ubiquitin complex interaction, and highlights a potential substrate hierarchy between the different MHC I alleles downregulated by K3. The I44A mutant also increases cell-surface MHC I expression in control cells in the absence of K3, predicting the presence of an endogenous E3 ubiquitin ligase required for cell-surface MHC I regulation." @default.
• W2115664315 created "2016-06-24" @default.
• W2115664315 creator A5057740429 @default.
• W2115664315 creator A5067793296 @default.
• W2115664315 creator A5075336505 @default.
• W2115664315 date "2010-06-15" @default.
• W2115664315 modified "2023-09-27" @default.
• W2115664315 title "Stabilization of an E3 Ligase–E2–Ubiquitin Complex Increases Cell Surface MHC Class I Expression" @default.
• W2115664315 cites W1840363873 @default.
• W2115664315 cites W1965378730 @default.
• W2115664315 cites W1965969172 @default.
• W2115664315 cites W1969807455 @default.
• W2115664315 cites W1986627314 @default.
• W2115664315 cites W1988617344 @default.
• W2115664315 cites W1996633441 @default.
• W2115664315 cites W2003434224 @default.
• W2115664315 cites W2009745195 @default.
• W2115664315 cites W2023662773 @default.
• W2115664315 cites W2024812887 @default.
• W2115664315 cites W2027966370 @default.
• W2115664315 cites W2037454778 @default.
• W2115664315 cites W2039925078 @default.
• W2115664315 cites W2040614735 @default.
• W2115664315 cites W2041517382 @default.
• W2115664315 cites W2048815297 @default.
• W2115664315 cites W2050043175 @default.
• W2115664315 cites W2064360143 @default.
• W2115664315 cites W2065602427 @default.
• W2115664315 cites W2069788390 @default.
• W2115664315 cites W2074876842 @default.
• W2115664315 cites W2077466422 @default.
• W2115664315 cites W2081376834 @default.
• W2115664315 cites W2087330517 @default.
• W2115664315 cites W2087922104 @default.
• W2115664315 cites W2088916557 @default.
• W2115664315 cites W2101090646 @default.
• W2115664315 cites W2104984927 @default.
• W2115664315 cites W2112385479 @default.
• W2115664315 cites W2116612021 @default.
• W2115664315 cites W2117396050 @default.
• W2115664315 cites W2118442022 @default.
• W2115664315 cites W2125905711 @default.
• W2115664315 cites W2129291354 @default.
• W2115664315 cites W2134320577 @default.
• W2115664315 cites W2135700703 @default.
• W2115664315 cites W2137885288 @default.
• W2115664315 cites W2137960852 @default.
• W2115664315 cites W2142424369 @default.
• W2115664315 cites W2143151869 @default.
• W2115664315 cites W2144114582 @default.
• W2115664315 cites W2144720739 @default.
• W2115664315 cites W2149368193 @default.
• W2115664315 cites W2149616074 @default.
• W2115664315 cites W2163909866 @default.
• W2115664315 cites W2170721499 @default.
• W2115664315 doi "https://doi.org/10.4049/jimmunol.0904154" @default.
• W2115664315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3551299" @default.
• W2115664315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20483773" @default.
• W2115664315 hasPublicationYear "2010" @default.
• W2115664315 type Work @default.
• W2115664315 sameAs 2115664315 @default.
• W2115664315 citedByCount "17" @default.
• W2115664315 countsByYear W21156643152012 @default.
• W2115664315 countsByYear W21156643152013 @default.
• W2115664315 countsByYear W21156643152014 @default.
• W2115664315 countsByYear W21156643152016 @default.
• W2115664315 countsByYear W21156643152017 @default.
• W2115664315 countsByYear W21156643152018 @default.
• W2115664315 countsByYear W21156643152021 @default.
• W2115664315 countsByYear W21156643152022 @default.
• W2115664315 countsByYear W21156643152023 @default.
• W2115664315 crossrefType "journal-article" @default.
• W2115664315 hasAuthorship W2115664315A5057740429 @default.
• W2115664315 hasAuthorship W2115664315A5067793296 @default.
• W2115664315 hasAuthorship W2115664315A5075336505 @default.
• W2115664315 hasBestOaLocation W21156643151 @default.
• W2115664315 hasConcept C104317684 @default.
• W2115664315 hasConcept C134459356 @default.
• W2115664315 hasConcept C1491633281 @default.
• W2115664315 hasConcept C153911025 @default.
• W2115664315 hasConcept C170627219 @default.
• W2115664315 hasConcept C175114707 @default.
• W2115664315 hasConcept C181199279 @default.
• W2115664315 hasConcept C207936829 @default.
• W2115664315 hasConcept C22845430 @default.
• W2115664315 hasConcept C25602115 @default.
• W2115664315 hasConcept C28005876 @default.
• W2115664315 hasConcept C54355233 @default.
• W2115664315 hasConcept C55493867 @default.
• W2115664315 hasConcept C86803240 @default.
• W2115664315 hasConcept C8891405 @default.
• W2115664315 hasConcept C95444343 @default.
• W2115664315 hasConceptScore W2115664315C104317684 @default.
• W2115664315 hasConceptScore W2115664315C134459356 @default.
• W2115664315 hasConceptScore W2115664315C1491633281 @default.
• W2115664315 hasConceptScore W2115664315C153911025 @default.
• W2115664315 hasConceptScore W2115664315C170627219 @default.
• W2115664315 hasConceptScore W2115664315C175114707 @default.

• next