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- W2115693995 abstract "Oxprenolol is a non-selective adrenergic beta-receptor antagonist displaying beta-mimetic activity. To test the hypothesis that beta-mimetic activity could minimize the response of the circulation to adrenergic beta-receptor blockade, cumulative dose-response curves to oxprenolol 0.1-1.6 mg kg-1 were obtained in seven anaesthetized dogs. Anaesthesia was maintained with 0.5% halothane supplementing nitrous oxide 66% in oxygen, under moderately hypocapnic IPPV. Oxprenolol, up to 0.4 mg kg-1 i.v., caused modest increases in heart rate, LV dP/dt max and cardiac output. With the largest dose (1.6 mg kg-1), significant increases in heart rate (+19%), LV dP/dt max (+13%) and cardiac output (+27%) were observed while arterial pressure remained unchanged and systemic vascular resistance decreased (-18%)." @default.
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- W2115693995 date "1981-05-01" @default.
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- W2115693995 title "OXPRENOLOL AND THE CIRCULATION DURING ANAESTHESIA IN THE DOG: INFLUENCE OF INTRINSIC SYMPATHOMIMETIC ACTIVITY" @default.
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- W2115693995 doi "https://doi.org/10.1093/bja/53.5.463" @default.
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