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• W2115719305 endingPage "800" @default.
• W2115719305 startingPage "795" @default.
• W2115719305 abstract "Several epidemiological studies have linked particulate matter exposure to numerous adverse health effects on the respiratory, cardiovascular, and reproductive systems (Braga et al., 1999; ; ; ). More recently, ambient levels of black carbon were associated to impaired cognitive function in children (), suggesting that the central nervous system (CNS) may be a target of air pollutants. The present study was conducted to (a) determine whether chronic residual oil fly ash (ROFA) exposure promotes behavioral changes and lipid peroxidation in rat brain areas, and (b) determine whether N-acetylcysteine (NAC), a general antioxidant, prevents these effects. Forty-five-day-old male Wistar rats were exposed or not to ROFA by intranasal instillation and were treated or not with NAC (150 mg/kg) ip for 30 days. One day later, rats were submitted to the open field test to evaluate the motor/exploratory activities and emotionality followed by decapitation. Striatum and cerebellum were dissected to determine lipid peroxidation by the accumulation of thiobarbituric acid-reactive substances (TBARS). ROFA instillation induced an increase in lipid peroxidation level in striatum (p = .033) and cerebellum (p = .030), as compared with the control group. NAC treatment blocked these changes. ROFA promoted a decrease in the frequency of peripheral walking (p = .006) and a decrease in exploration (p = .001), which were not blocked by N-acetylcysteine. The present study provides evidence that toxic particles, administered by the respiratory route, induce oxidative stress in structures of the central nervous system, as well as behavioral alterations. The administration of NAC reduces lipid peroxidation at the striatum and cerebellum levels, but does not influence behavioral disturbances." @default.
• W2115719305 created "2016-06-24" @default.
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• W2115719305 date "2008-01-01" @default.
• W2115719305 modified "2023-10-02" @default.
• W2115719305 title "Chronic Nasal Instillation of Residual-Oil Fly Ash (ROFA) Induces Brain Lipid Peroxidation and Behavioral Changes in Rats" @default.
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• W2115719305 doi "https://doi.org/10.1080/08958370802009060" @default.
• W2115719305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18645718" @default.
• W2115719305 hasPublicationYear "2008" @default.
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