Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115736199> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2115736199 endingPage "271" @default.
- W2115736199 startingPage "267" @default.
- W2115736199 abstract "The concentration and total amount of DNA in the livers of SD rats fed 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) gradually increased and reached a maximum in developing tumors. In SD rats fed 3'-Me-DAB plus disulfiram (DSF), the concentration of DNA was higher than in controls, but it soon became stabilzed and the total amount of DNA in the liver did not differ substantially from that in rats fed DSF alone. In rats given 3'-Me-DAB, neoplastic nodules and liver carcinomas appeared after 3 months, but in those fed both compounds these formations were absent even after 6 months. The activity of gamma-glutamyltransferase (GT-ase), a marker of chemically induced carcinogenesis in rat liver, gradually increased to extremely high levels in tumors even after 75 days when the diet of the animals was changed to a normal one. In rats fed 3'-Me-DAB plus DSF, GT-ase activity increased for the greater part of 80 days, gradually leveled off around the 100th day, and returned to almost normal levels when the rats were given a normal diet after 100 days. We concluded that DSF 1) did not interfere with 3'-Me-DAB-induced proliferation of preneoplastic cells and the increase in GT-ase associated with this reversible adaptation to the influx of 3'-Me-DAB; and 2) inhibited malignant transformation and, consequently, prevented the formation and proliferation of neoplastic cells and the increase in constitutive GT-ase related to neoplasia." @default.
- W2115736199 created "2016-06-24" @default.
- W2115736199 creator A5011563678 @default.
- W2115736199 creator A5033070896 @default.
- W2115736199 creator A5037142183 @default.
- W2115736199 creator A5087192765 @default.
- W2115736199 date "1980-02-01" @default.
- W2115736199 modified "2023-10-16" @default.
- W2115736199 title "γ-Glutamyltransferase and the Inhibition of Azo Dye-Produced Neoplasia by Concomitant Administration of Disulfiram23" @default.
- W2115736199 doi "https://doi.org/10.1093/jnci/64.2.267" @default.
- W2115736199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6101622" @default.
- W2115736199 hasPublicationYear "1980" @default.
- W2115736199 type Work @default.
- W2115736199 sameAs 2115736199 @default.
- W2115736199 citedByCount "11" @default.
- W2115736199 crossrefType "journal-article" @default.
- W2115736199 hasAuthorship W2115736199A5011563678 @default.
- W2115736199 hasAuthorship W2115736199A5033070896 @default.
- W2115736199 hasAuthorship W2115736199A5037142183 @default.
- W2115736199 hasAuthorship W2115736199A5087192765 @default.
- W2115736199 hasConcept C114246631 @default.
- W2115736199 hasConcept C121608353 @default.
- W2115736199 hasConcept C126322002 @default.
- W2115736199 hasConcept C134018914 @default.
- W2115736199 hasConcept C185592680 @default.
- W2115736199 hasConcept C2778523461 @default.
- W2115736199 hasConcept C2779384505 @default.
- W2115736199 hasConcept C2993273003 @default.
- W2115736199 hasConcept C552990157 @default.
- W2115736199 hasConcept C55493867 @default.
- W2115736199 hasConcept C555283112 @default.
- W2115736199 hasConcept C64241487 @default.
- W2115736199 hasConcept C71924100 @default.
- W2115736199 hasConcept C86803240 @default.
- W2115736199 hasConceptScore W2115736199C114246631 @default.
- W2115736199 hasConceptScore W2115736199C121608353 @default.
- W2115736199 hasConceptScore W2115736199C126322002 @default.
- W2115736199 hasConceptScore W2115736199C134018914 @default.
- W2115736199 hasConceptScore W2115736199C185592680 @default.
- W2115736199 hasConceptScore W2115736199C2778523461 @default.
- W2115736199 hasConceptScore W2115736199C2779384505 @default.
- W2115736199 hasConceptScore W2115736199C2993273003 @default.
- W2115736199 hasConceptScore W2115736199C552990157 @default.
- W2115736199 hasConceptScore W2115736199C55493867 @default.
- W2115736199 hasConceptScore W2115736199C555283112 @default.
- W2115736199 hasConceptScore W2115736199C64241487 @default.
- W2115736199 hasConceptScore W2115736199C71924100 @default.
- W2115736199 hasConceptScore W2115736199C86803240 @default.
- W2115736199 hasIssue "2" @default.
- W2115736199 hasLocation W21157361991 @default.
- W2115736199 hasLocation W21157361992 @default.
- W2115736199 hasOpenAccess W2115736199 @default.
- W2115736199 hasPrimaryLocation W21157361991 @default.
- W2115736199 hasRelatedWork W100212505 @default.
- W2115736199 hasRelatedWork W114834358 @default.
- W2115736199 hasRelatedWork W1517064303 @default.
- W2115736199 hasRelatedWork W180880871 @default.
- W2115736199 hasRelatedWork W1981791036 @default.
- W2115736199 hasRelatedWork W1990936130 @default.
- W2115736199 hasRelatedWork W1994774080 @default.
- W2115736199 hasRelatedWork W2037726393 @default.
- W2115736199 hasRelatedWork W2071845491 @default.
- W2115736199 hasRelatedWork W2412361774 @default.
- W2115736199 hasVolume "64" @default.
- W2115736199 isParatext "false" @default.
- W2115736199 isRetracted "false" @default.
- W2115736199 magId "2115736199" @default.
- W2115736199 workType "article" @default.