Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115763257> ?p ?o ?g. }
- W2115763257 endingPage "95" @default.
- W2115763257 startingPage "83" @default.
- W2115763257 abstract "Development and differentiation of the prostate from the fetal urogenital sinus (UGS) is dependent on androgen action via androgen receptors (AR) in the UGS mesenchyme. Estrogens are not required for prostate differentiation but do act to modulate androgen action. In mice exposure to exogenous estrogen during development results in permanent effects on adult prostate size and function, which is mediated through mesenchymal estrogen receptor (ER) alpha. For many years estrogens were thought to inhibit prostate growth because estrogenic drugs studied were administered at very high concentrations that interfered with normal prostate development. There is now extensive evidence that exposure to estrogen at very low concentrations during the early stages of prostate differentiation can stimulate fetal/neonatal prostate growth and lead to prostate disease in adulthood. Bisphenol A (BPA) is an environmental endocrine disrupting chemical that binds to both ER receptor subtypes as well as to AR. Interest in BPA has increased because of its prevalence in the environment and its detection in over 90% of people in the USA. In tissue culture of fetal mouse UGS mesenchymal cells, BPA and estradiol stimulated changes in the expression of several genes. We discuss here the potential involvement of estrogen in regulating signaling pathways affecting cellular functions relevant to steroid hormone signaling and metabolism and to inter- and intra-cellular communications that promote cell growth. The findings presented here provide additional evidence that BPA and the estrogenic drug ethinylestradiol disrupt prostate development in male mice at administered doses relevant to human exposures." @default.
- W2115763257 created "2016-06-24" @default.
- W2115763257 creator A5021920848 @default.
- W2115763257 creator A5028994823 @default.
- W2115763257 creator A5051514888 @default.
- W2115763257 creator A5056114543 @default.
- W2115763257 date "2011-10-01" @default.
- W2115763257 modified "2023-10-16" @default.
- W2115763257 title "Estrogenic environmental chemicals and drugs: Mechanisms for effects on the developing male urogenital system" @default.
- W2115763257 cites W1564796335 @default.
- W2115763257 cites W1965966912 @default.
- W2115763257 cites W1967211742 @default.
- W2115763257 cites W1967256854 @default.
- W2115763257 cites W1968422953 @default.
- W2115763257 cites W1968614586 @default.
- W2115763257 cites W1970358298 @default.
- W2115763257 cites W1971947104 @default.
- W2115763257 cites W1972022922 @default.
- W2115763257 cites W1973556480 @default.
- W2115763257 cites W1974240720 @default.
- W2115763257 cites W1977726417 @default.
- W2115763257 cites W1978152488 @default.
- W2115763257 cites W1985636914 @default.
- W2115763257 cites W1986126010 @default.
- W2115763257 cites W1987420224 @default.
- W2115763257 cites W1991891667 @default.
- W2115763257 cites W1994048261 @default.
- W2115763257 cites W1994413221 @default.
- W2115763257 cites W1996581537 @default.
- W2115763257 cites W1997348862 @default.
- W2115763257 cites W1997522657 @default.
- W2115763257 cites W2001090572 @default.
- W2115763257 cites W2002673092 @default.
- W2115763257 cites W2007888807 @default.
- W2115763257 cites W2010054556 @default.
- W2115763257 cites W2010559663 @default.
- W2115763257 cites W2014825118 @default.
- W2115763257 cites W2016171854 @default.
- W2115763257 cites W2016527659 @default.
- W2115763257 cites W2016836146 @default.
- W2115763257 cites W2018991261 @default.
- W2115763257 cites W2021064276 @default.
- W2115763257 cites W2022373675 @default.
- W2115763257 cites W2023652812 @default.
- W2115763257 cites W2024842895 @default.
- W2115763257 cites W2025226724 @default.
- W2115763257 cites W2026180592 @default.
- W2115763257 cites W2028787260 @default.
- W2115763257 cites W2030212544 @default.
- W2115763257 cites W2030772180 @default.
- W2115763257 cites W2032697189 @default.
- W2115763257 cites W2036142628 @default.
- W2115763257 cites W2037308071 @default.
- W2115763257 cites W2037367138 @default.
- W2115763257 cites W2039269175 @default.
- W2115763257 cites W2039871782 @default.
- W2115763257 cites W2040398116 @default.
- W2115763257 cites W2041554939 @default.
- W2115763257 cites W2041570934 @default.
- W2115763257 cites W2042062822 @default.
- W2115763257 cites W2044104475 @default.
- W2115763257 cites W2044527694 @default.
- W2115763257 cites W2048637593 @default.
- W2115763257 cites W2048657217 @default.
- W2115763257 cites W2048982634 @default.
- W2115763257 cites W2049513566 @default.
- W2115763257 cites W2049970571 @default.
- W2115763257 cites W2052046577 @default.
- W2115763257 cites W2052927712 @default.
- W2115763257 cites W2053309581 @default.
- W2115763257 cites W2055860855 @default.
- W2115763257 cites W2057598257 @default.
- W2115763257 cites W2057700119 @default.
- W2115763257 cites W2059732667 @default.
- W2115763257 cites W2060684880 @default.
- W2115763257 cites W2064854818 @default.
- W2115763257 cites W2066000490 @default.
- W2115763257 cites W2066856085 @default.
- W2115763257 cites W2067753015 @default.
- W2115763257 cites W2073353512 @default.
- W2115763257 cites W2073883348 @default.
- W2115763257 cites W2073890008 @default.
- W2115763257 cites W2074132268 @default.
- W2115763257 cites W2075654456 @default.
- W2115763257 cites W2077057958 @default.
- W2115763257 cites W2078222204 @default.
- W2115763257 cites W2079724894 @default.
- W2115763257 cites W2081094011 @default.
- W2115763257 cites W2081491312 @default.
- W2115763257 cites W2081746977 @default.
- W2115763257 cites W2083088211 @default.
- W2115763257 cites W2085661640 @default.
- W2115763257 cites W2086422581 @default.
- W2115763257 cites W2088514819 @default.
- W2115763257 cites W2090133455 @default.
- W2115763257 cites W2090991839 @default.
- W2115763257 cites W2091484792 @default.
- W2115763257 cites W2092475522 @default.