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- W2115764466 abstract "Object The role of surgery and adjuvant radiation therapy for cranial base chordomas is not well established. This meta-analysis measures the relationship of complete resection and type of adjuvant radiation therapy to 5-year progression-free survival (PFS) and overall survival (OS) of cranial base chordomas. Methods A systematic MEDLINE search (1999–present) yielded 23 observational studies and 807 patients who fit inclusion criteria. The following analyses were performed: 1) Kaplan-Meier 5-year PFS and OS compared based on the extent of resection and type of adjuvant radiation therapy using the log-rank method; 2) a random-effects model comparing 5-year PFS with complete or incomplete resection; and 3) paired z-test comparisons of weighted average 5-year OS and PFS grouped by type of adjuvant radiation therapy. Results The weighted average follow-up was 53.6 months. The weighted average 5-year PFS and OS were 50.8% and 78.4%, respectively. Complete resection conferred a higher 5-year PFS than incomplete..." @default.
- W2115764466 created "2016-06-24" @default.
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- W2115764466 date "2011-01-01" @default.
- W2115764466 modified "2023-09-26" @default.
- W2115764466 title "Current Comprehensive Management of Cranial Base Chordomas: 10-year Meta-Analysis of Observational Studies" @default.
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- W2115764466 doi "https://doi.org/10.1055/s-2011-1274311" @default.
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