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• W2115774646 abstract "The architecture of the heart remains controversial despite extensive effort and recent advances in imaging techniques. Several opposing and non-mutually compatible models have been proposed to explain cardiac structure, and these models, although limited, have advanced the study and understanding of heart structure, function and development. We describe key areas of similarity and difference, highlight areas of contention and point to the important limitations of these models. Recent research in animal models on the nature, geometry and interaction of cardiac sheet structure allows unification of some seemingly conflicting features of the structural models. Intriguingly, evidence points to significant inter-individual structural variability (within constrained limits) in the canine, leading to the concept of a continuum (or distribution) of cardiac structures. This variability in heart structure partly explains the ongoing debate on myocardial architecture. These developments are used to construct an integrated description of cardiac structure unifying features of fibre, sheet and band architecture that provides a basis for (i) explaining cardiac electromechanics, (ii) computational simulations of cardiac physiology and (iii) designing interventions." @default.
• W2115774646 created "2016-06-24" @default.
• W2115774646 creator A5028087836 @default.
• W2115774646 creator A5058444517 @default.
• W2115774646 creator A5083800253 @default.
• W2115774646 creator A5086290413 @default.
• W2115774646 date "2007-08-01" @default.
• W2115774646 modified "2023-10-14" @default.
• W2115774646 title "Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure" @default.
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• W2115774646 doi "https://doi.org/10.1016/j.ejcts.2007.03.032" @default.
• W2115774646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17462906" @default.
• W2115774646 hasPublicationYear "2007" @default.
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