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• W2115779097 abstract "Non-coding RNAs (ncRNAs) with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation with the discovery that most of the transcriptome is ncRNA. The prototype has long been the Xist ncRNA, which induces X-chromosome inactivation in female cells. However, a new paradigm is emerging – the silencing of imprinted gene clusters by long ncRNAs. Here, we review models by which imprinted ncRNAs could function. We argue that an Xist-like model is only one of many possible solutions and that imprinted ncRNAs could provide the better model for understanding the function of the new class of ncRNAs associated with non-imprinted mammalian genes. Non-coding RNAs (ncRNAs) with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation with the discovery that most of the transcriptome is ncRNA. The prototype has long been the Xist ncRNA, which induces X-chromosome inactivation in female cells. However, a new paradigm is emerging – the silencing of imprinted gene clusters by long ncRNAs. Here, we review models by which imprinted ncRNAs could function. We argue that an Xist-like model is only one of many possible solutions and that imprinted ncRNAs could provide the better model for understanding the function of the new class of ncRNAs associated with non-imprinted mammalian genes." @default.
• W2115779097 created "2016-06-24" @default.
• W2115779097 creator A5018457785 @default.
• W2115779097 creator A5046008529 @default.
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• W2115779097 date "2007-06-01" @default.
• W2115779097 modified "2023-09-26" @default.
• W2115779097 title "Silencing by imprinted noncoding RNAs: is transcription the answer?" @default.
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• W2115779097 doi "https://doi.org/10.1016/j.tig.2007.03.018" @default.
• W2115779097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847181" @default.
• W2115779097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17445943" @default.
• W2115779097 hasPublicationYear "2007" @default.
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