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• W2115790271 abstract "The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF − 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes." @default.
• W2115790271 created "2016-06-24" @default.
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• W2115790271 date "2015-01-21" @default.
• W2115790271 modified "2023-10-06" @default.
• W2115790271 title "Polymorphisms in<i>TNF</i>and<i>IFNG</i>are associated with clinical characteristics of aplastic anemia in Argentinean population" @default.
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• W2115790271 doi "https://doi.org/10.3109/10428194.2014.966707" @default.
• W2115790271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25248876" @default.
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