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• W2115806827 abstract "CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates terminating in α2, 6 sialic acid. The physiological ligand(s) for CD22 remain unknown. We asked whether the sialic acid binding domains are necessary for CD22 to function as a negative regulator. We generated two mutants that lack sialic acid binding activity and expressed them in a novel CD22−/− murine B cell line. Anti-IgM activated B cells expressing either CD22 mutant had greater Ca2+ responses than cells expressing wild-type CD22. Each variant also had reduced CD22 tyrosine phosphorylation and Src homology 2 domain–containing protein tyrosine phosphatase-1 association. These data suggest that the α2, 6 sialic acid ligand binding activity of CD22 is critical for its negative regulatory functions." @default.
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• W2115806827 date "2002-04-29" @default.
• W2115806827 modified "2023-09-26" @default.
• W2115806827 title "Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling" @default.
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• W2115806827 doi "https://doi.org/10.1084/jem.20011796" @default.
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