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• W2115813995 abstract "ABSTRACT The virulence of Candida albicans in a mouse model of invasive candidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). Disruption of the PS synthase gene CHO1 (i.e., cho1 Δ/Δ) eliminates PS and blocks the de novo pathway for PE biosynthesis. In addition, the cho1 Δ/Δ mutant's ability to cause invasive disease is severely compromised. The cho1 Δ/Δ mutant also exhibits cell wall defects, and in this study, it was determined that loss of PS results in decreased masking of cell wall β(1-3)-glucan from the immune system. In wild-type C. albicans , the outer mannan layer of the wall masks the inner layer of β(1-3)-glucan from exposure and detection by innate immune effector molecules like the C-type signaling lectin Dectin-1, which is found on macrophages, neutrophils, and dendritic cells. The cho1 Δ/Δ mutant exhibits increases in exposure of β(1-3)-glucan, which leads to greater binding by Dectin-1 in both yeast and hyphal forms. The unmasking of β(1-3)-glucan also results in increased elicitation of TNF-α from macrophages in a Dectin-1-dependent manner. The role of phospholipids in fungal pathogenesis is an emerging field, and this is the first study showing that loss of PS in C. albicans results in decreased masking of β(1-3)-glucan, which may contribute to our understanding of fungus-host interactions." @default.
• W2115813995 created "2016-06-24" @default.
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• W2115813995 date "2014-10-01" @default.
• W2115813995 modified "2023-10-14" @default.
• W2115813995 title "Masking of β(1-3)-Glucan in the Cell Wall of Candida albicans from Detection by Innate Immune Cells Depends on Phosphatidylserine" @default.
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• W2115813995 doi "https://doi.org/10.1128/iai.01612-14" @default.
• W2115813995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4187869" @default.
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