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• W2115815903 abstract "ABSTRACT Mucoidy, or overproduction of the exopolysaccharide known as alginate, in Pseudomonas aeruginosa is a poor prognosticator for lung infections in cystic fibrosis. Mutation of the anti-σ factor MucA is a well-accepted mechanism for mucoid conversion. However, certain clinical mucoid strains of P. aeruginosa have a wild-type (wt) mucA . Here, we describe a loss-of-function mutation in kinB that causes overproduction of alginate in the wt mucA strain PAO1. KinB is the cognate histidine kinase for the transcriptional activator AlgB. Increased alginate production due to inactivation of kinB was correlated with high expression at the alginate-related promoters P algU and P algD . Deletion of alternative σ factor RpoN (σ 54 ) or the response regulator AlgB in kinB mutants decreased alginate production to wt nonmucoid levels. Mucoidy was restored in the kinB algB double mutant by expression of wt AlgB or phosphorylation-defective AlgB.D59N, indicating that phosphorylation of AlgB was not required for alginate overproduction when kinB was inactivated. The inactivation of the DegS-like protease AlgW in the kinB mutant caused loss of alginate production and an accumulation of the hemagglutinin (HA)-tagged MucA. Furthermore, we observed that the kinB mutation increased the rate of HA-MucA degradation. Our results also indicate that AlgW-mediated MucA degradation required algB and rpoN in the kinB mutant. Collectively, these studies indicate that KinB is a negative regulator of alginate production in wt mucA strain PAO1." @default.
• W2115815903 created "2016-06-24" @default.
• W2115815903 creator A5034505623 @default.
• W2115815903 creator A5077458523 @default.
• W2115815903 creator A5077951368 @default.
• W2115815903 date "2009-04-01" @default.
• W2115815903 modified "2023-09-24" @default.
• W2115815903 title "The <i>Pseudomonas aeruginosa</i> Sensor Kinase KinB Negatively Controls Alginate Production through AlgW-Dependent MucA Proteolysis" @default.
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• W2115815903 doi "https://doi.org/10.1128/jb.01490-08" @default.
• W2115815903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655532" @default.
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