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• W2115825840 abstract "Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including industrial, agricultural, and pharmaceutical agents. Spontaneous HS arise frequently in mice, less commonly in rats, and frequently in numerous breeds of dogs. This review explores knowledge gaps and uncertainties related to the mode of action (MOA) for the induction of HS in rodents, and evaluates the potential relevance for human risk. For genotoxic chemicals (vinyl chloride and thorotrast), significant information is available concerning the MOA. In contrast, numerous chemicals produce HS in rodents by nongenotoxic, proliferative mechanisms. An overall framework is presented, including direct and indirect actions on endothelial cells, paracrine effects in local tissues, activation of bone marrow endothelial precursor cells, and tissue hypoxia. Numerous obstacles are identified in investigations into the MOA for mouse HS and the relevance of the mouse tumors to humans, including lack of identifiable precursor lesions, usually late occurrence of the tumors, and complexities of endothelial biology. This review proposes a working MOA for HS induced by nongenotoxic compounds that can guide future research in this area. Importantly, a common MOA appears to exist for the nongenotoxic induction of HS, where there appears to be a convergence of multiple initiating events (e.g., hemolysis, decreased respiration, adipocyte growth) leading to either dysregulated angiogenesis and/or erythropoiesis that results from hypoxia and macrophage activation. These later events lead to the release of angiogenic growth factors and cytokines that stimulate endothelial cell proliferation, which, if sustained, provide the milieu that can lead to HS formation." @default.
• W2115825840 created "2016-06-24" @default.
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• W2115825840 date "2009-06-12" @default.
• W2115825840 modified "2023-09-28" @default.
• W2115825840 title "Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance" @default.
• W2115825840 cites W103142017 @default.
• W2115825840 cites W1493048246 @default.
• W2115825840 cites W1963772784 @default.
• W2115825840 cites W1968391374 @default.
• W2115825840 cites W1970446344 @default.
• W2115825840 cites W1974068770 @default.
• W2115825840 cites W1979891446 @default.
• W2115825840 cites W1982246723 @default.
• W2115825840 cites W1990593799 @default.
• W2115825840 cites W1995574334 @default.
• W2115825840 cites W1998102786 @default.
• W2115825840 cites W1999239339 @default.
• W2115825840 cites W2000206516 @default.
• W2115825840 cites W2003067110 @default.
• W2115825840 cites W2007778360 @default.
• W2115825840 cites W2010488656 @default.
• W2115825840 cites W2012276721 @default.
• W2115825840 cites W2012650972 @default.
• W2115825840 cites W2013536138 @default.
• W2115825840 cites W2014309206 @default.
• W2115825840 cites W2016063285 @default.
• W2115825840 cites W2016876586 @default.
• W2115825840 cites W2017702486 @default.
• W2115825840 cites W2022310350 @default.
• W2115825840 cites W2023271280 @default.
• W2115825840 cites W2025665677 @default.
• W2115825840 cites W2026658319 @default.
• W2115825840 cites W2028256563 @default.
• W2115825840 cites W2030207960 @default.
• W2115825840 cites W2037395185 @default.
• W2115825840 cites W2039851322 @default.
• W2115825840 cites W2046651900 @default.
• W2115825840 cites W2048538454 @default.
• W2115825840 cites W2049716477 @default.
• W2115825840 cites W2051051060 @default.
• W2115825840 cites W2053242629 @default.
• W2115825840 cites W2058326333 @default.
• W2115825840 cites W2060937998 @default.
• W2115825840 cites W2064360454 @default.
• W2115825840 cites W2074416459 @default.
• W2115825840 cites W2074610505 @default.
• W2115825840 cites W2080433269 @default.
• W2115825840 cites W2081270662 @default.
• W2115825840 cites W2082527320 @default.
• W2115825840 cites W2084994572 @default.
• W2115825840 cites W2096599017 @default.
• W2115825840 cites W2098801491 @default.
• W2115825840 cites W2100739884 @default.
• W2115825840 cites W2106858779 @default.
• W2115825840 cites W2107800413 @default.
• W2115825840 cites W2110516303 @default.
• W2115825840 cites W2119764044 @default.
• W2115825840 cites W2123684807 @default.
• W2115825840 cites W2124501162 @default.
• W2115825840 cites W2125090169 @default.
• W2115825840 cites W2126209600 @default.
• W2115825840 cites W2126426760 @default.
• W2115825840 cites W2127798219 @default.
• W2115825840 cites W2134489589 @default.
• W2115825840 cites W2138289723 @default.
• W2115825840 cites W2144026946 @default.
• W2115825840 cites W2146976723 @default.
• W2115825840 cites W2150603714 @default.
• W2115825840 cites W2155491988 @default.
• W2115825840 cites W2157686217 @default.
• W2115825840 cites W2159000056 @default.
• W2115825840 cites W2159684898 @default.
• W2115825840 cites W2169838161 @default.
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• W2115825840 doi "https://doi.org/10.1093/toxsci/kfp131" @default.
• W2115825840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19525443" @default.
• W2115825840 hasPublicationYear "2009" @default.
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