FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115829992> ?p ?o ?g. }

• W2115829992 endingPage "6421" @default.
• W2115829992 startingPage "6411" @default.
• W2115829992 abstract "Two glycosyltransferases that transfer sugars to EGF domains, OFUT1 and Fringe, regulate Notch signaling. However, sites of O-fucosylation on Notch that influence Notch activation have not been previously identified. Moreover, the influences of OFUT1 and Fringe on Notch activation can be positive or negative, depending on their levels of expression and on whether Delta or Serrate is signaling to Notch. Here, we describe the consequences of eliminating individual, highly conserved sites of O-fucose attachment to Notch. Our results indicate that glycosylation of an EGF domain proposed to be essential for ligand binding, EGF12, is crucial to the inhibition of Serrate-to-Notch signaling by Fringe. Expression of an EGF12 mutant of Notch(N-EGF12f) allows Notch activation by Serrate even in the presence of Fringe. By contrast, elimination of three other highly conserved sites of O-fucosylation does not have detectable effects. Binding assays with a soluble Notch extracellular domain fusion protein and ligand-expressing cells indicate that the NEGF12f mutation can influence Notch activation by preventing Fringe from blocking Notch-Serrate binding. The N-EGF12f mutant can substitute for endogenous Notch during embryonic neurogenesis, but not at the dorsoventral boundary of the wing. Thus, inhibition of Notch-Serrate binding by O-fucosylation of EGF12 might be needed in certain contexts to allow efficient Notch signaling." @default.
• W2115829992 created "2016-06-24" @default.
• W2115829992 creator A5033061394 @default.
• W2115829992 creator A5070242749 @default.
• W2115829992 creator A5071303454 @default.
• W2115829992 creator A5071660392 @default.
• W2115829992 date "2003-12-29" @default.
• W2115829992 modified "2023-10-03" @default.
• W2115829992 title "An<i>O</i>-fucose site in the ligand binding domain inhibits Notch activation" @default.
• W2115829992 cites W1887673845 @default.
• W2115829992 cites W1901052528 @default.
• W2115829992 cites W1953527695 @default.
• W2115829992 cites W1964633462 @default.
• W2115829992 cites W1966244724 @default.
• W2115829992 cites W1967115518 @default.
• W2115829992 cites W1968146121 @default.
• W2115829992 cites W1968343429 @default.
• W2115829992 cites W1975561755 @default.
• W2115829992 cites W1975771868 @default.
• W2115829992 cites W1976686299 @default.
• W2115829992 cites W1989292359 @default.
• W2115829992 cites W1989556421 @default.
• W2115829992 cites W1990803574 @default.
• W2115829992 cites W1998146679 @default.
• W2115829992 cites W2003377692 @default.
• W2115829992 cites W2019589453 @default.
• W2115829992 cites W2021803232 @default.
• W2115829992 cites W2034466289 @default.
• W2115829992 cites W2040362901 @default.
• W2115829992 cites W2041396837 @default.
• W2115829992 cites W2042956754 @default.
• W2115829992 cites W2045790644 @default.
• W2115829992 cites W2053483926 @default.
• W2115829992 cites W2067975978 @default.
• W2115829992 cites W2078497756 @default.
• W2115829992 cites W2080619964 @default.
• W2115829992 cites W2090218100 @default.
• W2115829992 cites W2095666604 @default.
• W2115829992 cites W2098268993 @default.
• W2115829992 cites W2098741226 @default.
• W2115829992 cites W2109744312 @default.
• W2115829992 cites W2110287546 @default.
• W2115829992 cites W2114688668 @default.
• W2115829992 cites W2117789426 @default.
• W2115829992 cites W2120097537 @default.
• W2115829992 cites W2124769526 @default.
• W2115829992 cites W2133039688 @default.
• W2115829992 cites W2141243765 @default.
• W2115829992 cites W2142916161 @default.
• W2115829992 cites W2143760153 @default.
• W2115829992 cites W2146129198 @default.
• W2115829992 cites W2149008219 @default.
• W2115829992 cites W2153298317 @default.
• W2115829992 cites W2154185559 @default.
• W2115829992 cites W2154861644 @default.
• W2115829992 cites W2162097271 @default.
• W2115829992 cites W2166698175 @default.
• W2115829992 cites W2183722523 @default.
• W2115829992 cites W2187570082 @default.
• W2115829992 cites W2483951904 @default.
• W2115829992 doi "https://doi.org/10.1242/dev.00883" @default.
• W2115829992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14627724" @default.
• W2115829992 hasPublicationYear "2003" @default.
• W2115829992 type Work @default.
• W2115829992 sameAs 2115829992 @default.
• W2115829992 citedByCount "89" @default.
• W2115829992 countsByYear W21158299922012 @default.
• W2115829992 countsByYear W21158299922013 @default.
• W2115829992 countsByYear W21158299922014 @default.
• W2115829992 countsByYear W21158299922016 @default.
• W2115829992 countsByYear W21158299922017 @default.
• W2115829992 countsByYear W21158299922018 @default.
• W2115829992 countsByYear W21158299922019 @default.
• W2115829992 countsByYear W21158299922020 @default.
• W2115829992 countsByYear W21158299922021 @default.
• W2115829992 countsByYear W21158299922022 @default.
• W2115829992 countsByYear W21158299922023 @default.
• W2115829992 crossrefType "journal-article" @default.
• W2115829992 hasAuthorship W2115829992A5033061394 @default.
• W2115829992 hasAuthorship W2115829992A5070242749 @default.
• W2115829992 hasAuthorship W2115829992A5071303454 @default.
• W2115829992 hasAuthorship W2115829992A5071660392 @default.
• W2115829992 hasBestOaLocation W21158299921 @default.
• W2115829992 hasConcept C104317684 @default.
• W2115829992 hasConcept C107824862 @default.
• W2115829992 hasConcept C108625454 @default.
• W2115829992 hasConcept C116227048 @default.
• W2115829992 hasConcept C116569031 @default.
• W2115829992 hasConcept C143065580 @default.
• W2115829992 hasConcept C153660203 @default.
• W2115829992 hasConcept C153911025 @default.
• W2115829992 hasConcept C161879069 @default.
• W2115829992 hasConcept C170493617 @default.
• W2115829992 hasConcept C202769670 @default.
• W2115829992 hasConcept C25166345 @default.
• W2115829992 hasConcept C2776841590 @default.
• W2115829992 hasConcept C2779212266 @default.
• W2115829992 hasConcept C2780645649 @default.

• next