FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115857330> ?p ?o ?g. }

• W2115857330 endingPage "2519" @default.
• W2115857330 startingPage "2510" @default.
• W2115857330 abstract "Synaptic vesicles are released stochastically, and therefore stimuli that increase a neuron's synaptic input might increase noise at its spike output. Indeed this appears true for neurons in primary visual cortex, where spike output variability increases with stimulus contrast. But in retinal ganglion cells, although intracellular recordings (with spikes blocked) showed that stronger stimuli increase membrane fluctuations, extracellular recordings showed that noise at the spike output is constant. Here we show that these seemingly paradoxical findings occur in the same cell and explain why. We made intracellular recordings from ganglion cells, in vitro, and presented periodic stimuli of various contrasts. For each stimulus cycle, we measured the response at the stimulus frequency (F1) for both membrane potential and spikes as well as the spike rate. The membrane and spike F1 response increased with contrast, but noise (SD) in the F1 responses and the spike rate was constant. We also measured membrane fluctuations (with spikes blocked) during the response depolarization and found that they did increase with contrast. However, increases in fluctuation amplitude were small relative to the depolarization (<10% at high contrast). A model based on estimated synaptic convergence, release rates, and membrane properties accounted for the relative magnitudes of fluctuations and depolarization. Furthermore, a cell's peak spike response preceded the peak depolarization, and therefore fluctuation amplitude peaked as the spike response declined. We conclude that two extremely general properties of a neuron, synaptic convergence and spike generation, combine to minimize the effects of membrane fluctuations on spiking." @default.
• W2115857330 created "2016-06-24" @default.
• W2115857330 creator A5037894693 @default.
• W2115857330 creator A5055727433 @default.
• W2115857330 creator A5062673695 @default.
• W2115857330 date "2004-10-01" @default.
• W2115857330 modified "2023-09-25" @default.
• W2115857330 title "How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output" @default.
• W2115857330 cites W142790015 @default.
• W2115857330 cites W1505038301 @default.
• W2115857330 cites W1555852936 @default.
• W2115857330 cites W1576002992 @default.
• W2115857330 cites W1594210692 @default.
• W2115857330 cites W1612963976 @default.
• W2115857330 cites W1627384048 @default.
• W2115857330 cites W1673584506 @default.
• W2115857330 cites W1770930219 @default.
• W2115857330 cites W1853085112 @default.
• W2115857330 cites W1885232817 @default.
• W2115857330 cites W1939828159 @default.
• W2115857330 cites W1961799769 @default.
• W2115857330 cites W1964800013 @default.
• W2115857330 cites W1968222117 @default.
• W2115857330 cites W1968599872 @default.
• W2115857330 cites W1972339319 @default.
• W2115857330 cites W1972864926 @default.
• W2115857330 cites W1974304595 @default.
• W2115857330 cites W1982579262 @default.
• W2115857330 cites W1988849438 @default.
• W2115857330 cites W1994868555 @default.
• W2115857330 cites W1995165699 @default.
• W2115857330 cites W2003714562 @default.
• W2115857330 cites W2014472560 @default.
• W2115857330 cites W2017108196 @default.
• W2115857330 cites W2019723923 @default.
• W2115857330 cites W2028546686 @default.
• W2115857330 cites W2029220906 @default.
• W2115857330 cites W2031678336 @default.
• W2115857330 cites W2032774941 @default.
• W2115857330 cites W2036144665 @default.
• W2115857330 cites W2037616194 @default.
• W2115857330 cites W2042422091 @default.
• W2115857330 cites W2044181537 @default.
• W2115857330 cites W2046075953 @default.
• W2115857330 cites W2047408446 @default.
• W2115857330 cites W2065621419 @default.
• W2115857330 cites W2069362932 @default.
• W2115857330 cites W2074942478 @default.
• W2115857330 cites W2080314397 @default.
• W2115857330 cites W2088931889 @default.
• W2115857330 cites W2093414300 @default.
• W2115857330 cites W2098957195 @default.
• W2115857330 cites W2110090036 @default.
• W2115857330 cites W2110928728 @default.
• W2115857330 cites W2114509411 @default.
• W2115857330 cites W2115135130 @default.
• W2115857330 cites W2115135943 @default.
• W2115857330 cites W2130143700 @default.
• W2115857330 cites W2138704896 @default.
• W2115857330 cites W2155776375 @default.
• W2115857330 cites W2166414874 @default.
• W2115857330 cites W2170154592 @default.
• W2115857330 cites W2418343484 @default.
• W2115857330 cites W4294214781 @default.
• W2115857330 doi "https://doi.org/10.1152/jn.00108.2004" @default.
• W2115857330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15175375" @default.
• W2115857330 hasPublicationYear "2004" @default.
• W2115857330 type Work @default.
• W2115857330 sameAs 2115857330 @default.
• W2115857330 citedByCount "25" @default.
• W2115857330 countsByYear W21158573302013 @default.
• W2115857330 countsByYear W21158573302016 @default.
• W2115857330 countsByYear W21158573302017 @default.
• W2115857330 countsByYear W21158573302018 @default.
• W2115857330 countsByYear W21158573302022 @default.
• W2115857330 crossrefType "journal-article" @default.
• W2115857330 hasAuthorship W2115857330A5037894693 @default.
• W2115857330 hasAuthorship W2115857330A5055727433 @default.
• W2115857330 hasAuthorship W2115857330A5062673695 @default.
• W2115857330 hasConcept C119599485 @default.
• W2115857330 hasConcept C12554922 @default.
• W2115857330 hasConcept C127413603 @default.
• W2115857330 hasConcept C15744967 @default.
• W2115857330 hasConcept C169760540 @default.
• W2115857330 hasConcept C181911157 @default.
• W2115857330 hasConcept C185263204 @default.
• W2115857330 hasConcept C185592680 @default.
• W2115857330 hasConcept C2778794669 @default.
• W2115857330 hasConcept C2779918689 @default.
• W2115857330 hasConcept C4141045 @default.
• W2115857330 hasConcept C542102704 @default.
• W2115857330 hasConcept C79879829 @default.
• W2115857330 hasConcept C81370116 @default.
• W2115857330 hasConcept C86803240 @default.
• W2115857330 hasConcept C95444343 @default.
• W2115857330 hasConceptScore W2115857330C119599485 @default.
• W2115857330 hasConceptScore W2115857330C12554922 @default.
• W2115857330 hasConceptScore W2115857330C127413603 @default.

• next