FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115858862> ?p ?o ?g. }

• W2115858862 endingPage "462" @default.
• W2115858862 startingPage "450" @default.
• W2115858862 abstract "BACKGROUND AND PURPOSE: Reports of MR imaging in hypothalamic hamartomas associated with epilepsy are few, and the number of patients studied is small. We aimed to detail the relationship of hypothalamic hamartomas to surrounding structures, to determine the frequency and nature of associated abnormalities, and to gain insight into mechanisms of epileptogenesis. METHODS: We systematically examined MR imaging studies of 72 patients with hypothalamic hamartoma and refractory epilepsy (patient age, 22 months to 31 years). A dedicated imaging protocol was used in 38 cases. Proton MR spectroscopy of the hypothalamic hamartoma was performed for 19 patients and compared with the metabolite profile of the thalamus in 10 normal children and the frontal lobe in 10 normal adults. RESULTS: Compared with normal gray matter, hypothalamic hamartomas were hyperintense on T2-weighted images (93%), hypointense on T1-weighted images (74%), and had reduced N-acetylaspartate and increased myoinositol content shown by MR spectroscopy. Hypothalamic hamartomas always involved the mammillary region of the hypothalamus, with attachment to one or both mammillary bodies. Intrahypothalamic extension (noted in 97%) tended to displace the postcommissural fornix and hypothalamic gray matter anterolaterally, such that the hypothalamic hamartomas nestled between the fornix, the mammillary body, and the mammillothalamic tract. Larger hamartoma size was associated with central precocious puberty. Associated findings of questionable epileptic significance included anterior temporal white matter signal intensity abnormalities (16%) and arachnoid cysts (6%). Malformations of cortical development were observed in only two patients, and hippocampal sclerosis was not observed. CONCLUSIONS: Hypothalamic hamartomas can be readily distinguished from normal hypothalamic gray and adjacent myelinated fiber tracts, best appreciated on thin T2-weighted images. MR imaging and spectroscopy suggest reduced neuronal density and relative gliosis compared with normal gray matter. Associated epileptogenic lesions are rare, supporting the view that the hypothalamic hamartoma alone is responsible for the typical clinical features of the syndrome. The intimate relationship to the mammillary body, fornix, and mammillothalamic tract suggests a role for these structures in epileptogenesis associated with hypothalamic hamartomas." @default.
• W2115858862 created "2016-06-24" @default.
• W2115858862 creator A5007508562 @default.
• W2115858862 creator A5025028778 @default.
• W2115858862 creator A5029318499 @default.
• W2115858862 creator A5030389436 @default.
• W2115858862 creator A5056695807 @default.
• W2115858862 creator A5074818367 @default.
• W2115858862 creator A5090134201 @default.
• W2115858862 creator A5090945411 @default.
• W2115858862 date "2004-03-01" @default.
• W2115858862 modified "2023-10-17" @default.
• W2115858862 title "MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases." @default.
• W2115858862 cites W1479790262 @default.
• W2115858862 cites W1492248647 @default.
• W2115858862 cites W1507644392 @default.
• W2115858862 cites W1537340239 @default.
• W2115858862 cites W1660591575 @default.
• W2115858862 cites W1745420251 @default.
• W2115858862 cites W1819369807 @default.
• W2115858862 cites W1875652007 @default.
• W2115858862 cites W1892244741 @default.
• W2115858862 cites W1969884631 @default.
• W2115858862 cites W1977365268 @default.
• W2115858862 cites W1978343926 @default.
• W2115858862 cites W1979159395 @default.
• W2115858862 cites W1983931666 @default.
• W2115858862 cites W1985720325 @default.
• W2115858862 cites W1992358076 @default.
• W2115858862 cites W1994659213 @default.
• W2115858862 cites W1997189763 @default.
• W2115858862 cites W1999231907 @default.
• W2115858862 cites W2002735980 @default.
• W2115858862 cites W2004834493 @default.
• W2115858862 cites W2005910968 @default.
• W2115858862 cites W2008248164 @default.
• W2115858862 cites W2014484839 @default.
• W2115858862 cites W2017456226 @default.
• W2115858862 cites W2025963445 @default.
• W2115858862 cites W2026808566 @default.
• W2115858862 cites W2028306771 @default.
• W2115858862 cites W2031576843 @default.
• W2115858862 cites W2032146895 @default.
• W2115858862 cites W2032649549 @default.
• W2115858862 cites W2036961997 @default.
• W2115858862 cites W2038973839 @default.
• W2115858862 cites W2038979894 @default.
• W2115858862 cites W2041171537 @default.
• W2115858862 cites W2042663218 @default.
• W2115858862 cites W2045277925 @default.
• W2115858862 cites W2055935373 @default.
• W2115858862 cites W2060649966 @default.
• W2115858862 cites W2065353204 @default.
• W2115858862 cites W2081564004 @default.
• W2115858862 cites W2082022626 @default.
• W2115858862 cites W2083840314 @default.
• W2115858862 cites W2087905211 @default.
• W2115858862 cites W2094474685 @default.
• W2115858862 cites W2095040453 @default.
• W2115858862 cites W2105885719 @default.
• W2115858862 cites W2107226846 @default.
• W2115858862 cites W2107759256 @default.
• W2115858862 cites W2112523966 @default.
• W2115858862 cites W2114622428 @default.
• W2115858862 cites W2116317791 @default.
• W2115858862 cites W2117325392 @default.
• W2115858862 cites W2118873880 @default.
• W2115858862 cites W2136830080 @default.
• W2115858862 cites W2139919068 @default.
• W2115858862 cites W2144418257 @default.
• W2115858862 cites W2149861895 @default.
• W2115858862 cites W2151109481 @default.
• W2115858862 cites W2155417601 @default.
• W2115858862 cites W2159298153 @default.
• W2115858862 cites W2163963130 @default.
• W2115858862 cites W2168879263 @default.
• W2115858862 cites W2183049732 @default.
• W2115858862 cites W2312480626 @default.
• W2115858862 cites W2402865959 @default.
• W2115858862 cites W2409883442 @default.
• W2115858862 cites W2411581129 @default.
• W2115858862 cites W2977017199 @default.
• W2115858862 cites W2056469736 @default.
• W2115858862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8158567" @default.
• W2115858862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037472" @default.
• W2115858862 hasPublicationYear "2004" @default.
• W2115858862 type Work @default.
• W2115858862 sameAs 2115858862 @default.
• W2115858862 citedByCount "54" @default.
• W2115858862 countsByYear W21158588622012 @default.
• W2115858862 countsByYear W21158588622013 @default.
• W2115858862 countsByYear W21158588622014 @default.
• W2115858862 countsByYear W21158588622015 @default.
• W2115858862 countsByYear W21158588622016 @default.
• W2115858862 countsByYear W21158588622017 @default.
• W2115858862 countsByYear W21158588622018 @default.
• W2115858862 countsByYear W21158588622019 @default.
• W2115858862 countsByYear W21158588622020 @default.

• next