Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115859969> ?p ?o ?g. }
- W2115859969 endingPage "315" @default.
- W2115859969 startingPage "305" @default.
- W2115859969 abstract "Resveratrol, a naturally occurring polyphenol, has been reported to be an anti-tumor and chemopreventive agent. Recent data show that it may also exert anti-angiogenic effects. We hypothesized that the anti-angiogenic activity of resveratrol may be caused by modulation of tumor cell release of thrombospondin-1 (TSP1) and vascular endothelial growth factor (VEGF) into the extracellular matrix, leading to vascular endothelial cell (VEC) apoptosis. We therefore evaluated the effects of resveratrol on melanoma cell lines co-cultured with vascular endothelial cells in monolayer and in three dimensional spheroids. We found that resveratrol stimulated isolated VEC proliferation, while it caused growth inhibition of VECs grown with melanoma cells in three-dimensional co-culture. This effect was associated with increased melanoma cell expression of tumor suppressor protein 53 and matrix protein TSP1, as well as decreased hypoxia-driven expression of hypoxia inducible factor-1α and inhibition of VEGF production." @default.
- W2115859969 created "2016-06-24" @default.
- W2115859969 creator A5008545738 @default.
- W2115859969 creator A5010699606 @default.
- W2115859969 creator A5020847537 @default.
- W2115859969 creator A5034332691 @default.
- W2115859969 creator A5061918246 @default.
- W2115859969 date "2010-10-07" @default.
- W2115859969 modified "2023-09-29" @default.
- W2115859969 title "Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture" @default.
- W2115859969 cites W1227080404 @default.
- W2115859969 cites W1530839362 @default.
- W2115859969 cites W157402533 @default.
- W2115859969 cites W1580865462 @default.
- W2115859969 cites W177380973 @default.
- W2115859969 cites W1975160071 @default.
- W2115859969 cites W1977601636 @default.
- W2115859969 cites W1985048556 @default.
- W2115859969 cites W1987418104 @default.
- W2115859969 cites W1993170641 @default.
- W2115859969 cites W1994947106 @default.
- W2115859969 cites W1998320552 @default.
- W2115859969 cites W1999984155 @default.
- W2115859969 cites W2000400362 @default.
- W2115859969 cites W2001254434 @default.
- W2115859969 cites W2002610797 @default.
- W2115859969 cites W2007799501 @default.
- W2115859969 cites W2015344488 @default.
- W2115859969 cites W2018069344 @default.
- W2115859969 cites W2021689192 @default.
- W2115859969 cites W2025476423 @default.
- W2115859969 cites W2026671371 @default.
- W2115859969 cites W2033791403 @default.
- W2115859969 cites W2035721941 @default.
- W2115859969 cites W2041683594 @default.
- W2115859969 cites W2045552152 @default.
- W2115859969 cites W2060118799 @default.
- W2115859969 cites W2062026123 @default.
- W2115859969 cites W2076746552 @default.
- W2115859969 cites W2076820945 @default.
- W2115859969 cites W2080178684 @default.
- W2115859969 cites W2086903333 @default.
- W2115859969 cites W2089916163 @default.
- W2115859969 cites W2090493150 @default.
- W2115859969 cites W2092722802 @default.
- W2115859969 cites W2102950926 @default.
- W2115859969 cites W2117906569 @default.
- W2115859969 cites W2120383690 @default.
- W2115859969 cites W2134710794 @default.
- W2115859969 cites W2136242764 @default.
- W2115859969 cites W2136830554 @default.
- W2115859969 cites W2141046053 @default.
- W2115859969 cites W2143778153 @default.
- W2115859969 cites W2146221483 @default.
- W2115859969 cites W2146260726 @default.
- W2115859969 cites W2148419067 @default.
- W2115859969 cites W2151089147 @default.
- W2115859969 cites W2155590575 @default.
- W2115859969 cites W2157550167 @default.
- W2115859969 cites W2166185936 @default.
- W2115859969 cites W2166280494 @default.
- W2115859969 cites W2319962899 @default.
- W2115859969 cites W2334988436 @default.
- W2115859969 cites W2408475944 @default.
- W2115859969 cites W2804842145 @default.
- W2115859969 doi "https://doi.org/10.1007/s10456-010-9187-8" @default.
- W2115859969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2980626" @default.
- W2115859969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20927579" @default.
- W2115859969 hasPublicationYear "2010" @default.
- W2115859969 type Work @default.
- W2115859969 sameAs 2115859969 @default.
- W2115859969 citedByCount "96" @default.
- W2115859969 countsByYear W21158599692012 @default.
- W2115859969 countsByYear W21158599692013 @default.
- W2115859969 countsByYear W21158599692014 @default.
- W2115859969 countsByYear W21158599692015 @default.
- W2115859969 countsByYear W21158599692016 @default.
- W2115859969 countsByYear W21158599692017 @default.
- W2115859969 countsByYear W21158599692018 @default.
- W2115859969 countsByYear W21158599692019 @default.
- W2115859969 countsByYear W21158599692020 @default.
- W2115859969 countsByYear W21158599692021 @default.
- W2115859969 countsByYear W21158599692022 @default.
- W2115859969 countsByYear W21158599692023 @default.
- W2115859969 crossrefType "journal-article" @default.
- W2115859969 hasAuthorship W2115859969A5008545738 @default.
- W2115859969 hasAuthorship W2115859969A5010699606 @default.
- W2115859969 hasAuthorship W2115859969A5020847537 @default.
- W2115859969 hasAuthorship W2115859969A5034332691 @default.
- W2115859969 hasAuthorship W2115859969A5061918246 @default.
- W2115859969 hasBestOaLocation W21158599691 @default.
- W2115859969 hasConcept C109523444 @default.
- W2115859969 hasConcept C123012128 @default.
- W2115859969 hasConcept C146285616 @default.
- W2115859969 hasConcept C1491633281 @default.
- W2115859969 hasConcept C167734588 @default.
- W2115859969 hasConcept C167814343 @default.
- W2115859969 hasConcept C185592680 @default.